Document Detail


Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases:Beneficial Effect of Docosahexaenoic Acid on Cognitive Decline in Alzheimer's Disease.
MedLine Citation:
PMID:  21606627     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Docosahexaenoic acid (DHA, C22:6 n-3), the most abundant n-3 polyunsaturated fatty acid in the brain, is essential for brain growth and development. Recent evidence has indicated the potential health benefits of DHA for managing Alzheimer's disease (AD). For example, dietary administration of DHA considerably protects against and ameliorates the impairment of learning ability in amyloid-beta (Aβ)(1-40)-infused AD-model rats, with concurrent increases in DHA levels and decreases in the levels of lipid peroxide and reactive oxygen species in the cortico-hippocampal tissues. In addition, dietary DHA helps in eliminating the amyloid burden from the brains of AD-model rats. In vitro studies have revealed that DHA substantially inhibits Aβ fibrillation. Furthermore, DHA reduces amyloid-induced toxicity in cell culture. These in vitro data support the hypothesis that DHA can ameliorate the cognitive deficits of AD in vivo by limiting Aβ polymerization in the brains. Therefore, it might be a useful therapeutic agent to prevent and/or delay cognitive impairment in mild cases of AD.
Authors:
Michio Hashimoto; Shahdat Hossain
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-21
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  -     ISSN:  1347-8648     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Environmental Physiology, Shimane University Faculty of Medicine, Japan.
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