| Neuroprotective actions of the synthetic estrogen 17alpha-ethynylestradiol in the hippocampus. | |
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MedLine Citation:
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PMID: 20044777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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17alpha-ethynylestradiol (EE2), a major constituent of many oral contraceptives, is similar in structure to 17beta-estradiol, which has neuroprotective properties in several animal models. This study explored the potential neuroprotective actions of EE2 against kainic and quinolinic acid toxicity in the hippocampus of adult ovariectomized Wistar rats. A decrease in the number of Nissl-stained neurons and the induction of vimentin immunoreactivity in astrocytes was observed in the hilus of the dentate gyrus of the hippocampus after the administration of either kainic acid or quinolinic acid. EE2 prevented the neuronal loss and the induction of vimentin immunoreactivity induced by kainic acid at low (1 microg/rat) and high (10-100 microg/rat) doses and exerted a protection against quinolinic acid toxicity at a low dose (1 microg/rat) only. These observations demonstrate that EE2 exerts neuroprotective actions against excitotoxic insults. This finding is relevant for the design of new neuroprotective estrogenic compounds. |
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Authors:
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Ofir Picazo; Adriana Becerril-Montes; Delia Huidobro-Perez; Luis M Garcia-Segura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-01 |
Journal Detail:
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Title: Cellular and molecular neurobiology Volume: 30 ISSN: 1573-6830 ISO Abbreviation: Cell. Mol. Neurobiol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200709 Medline TA: Cell Mol Neurobiol Country: United States |
Other Details:
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Languages: eng Pagination: 675-82 Citation Subset: IM |
Affiliation:
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Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón Col. Sto. Tomás, 11340 Mexico DF, Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Cyclodextrins / pharmacology Dentate Gyrus / cytology, drug effects, metabolism Ethinyl Estradiol / analogs & derivatives, pharmacology* Female Hippocampus / cytology*, drug effects*, metabolism Kainic Acid / pharmacology Neurons / cytology, drug effects Neuroprotective Agents / pharmacology* Ovariectomy Rats Rats, Wistar Staining and Labeling Vimentin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cyclodextrins; 0/Neuroprotective Agents; 0/Vimentin; 487-79-6/Kainic Acid; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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