Document Detail

Neuroprotective actions of the synthetic estrogen 17alpha-ethynylestradiol in the hippocampus.
MedLine Citation:
PMID:  20044777     Owner:  NLM     Status:  MEDLINE    
17alpha-ethynylestradiol (EE2), a major constituent of many oral contraceptives, is similar in structure to 17beta-estradiol, which has neuroprotective properties in several animal models. This study explored the potential neuroprotective actions of EE2 against kainic and quinolinic acid toxicity in the hippocampus of adult ovariectomized Wistar rats. A decrease in the number of Nissl-stained neurons and the induction of vimentin immunoreactivity in astrocytes was observed in the hilus of the dentate gyrus of the hippocampus after the administration of either kainic acid or quinolinic acid. EE2 prevented the neuronal loss and the induction of vimentin immunoreactivity induced by kainic acid at low (1 microg/rat) and high (10-100 microg/rat) doses and exerted a protection against quinolinic acid toxicity at a low dose (1 microg/rat) only. These observations demonstrate that EE2 exerts neuroprotective actions against excitotoxic insults. This finding is relevant for the design of new neuroprotective estrogenic compounds.
Ofir Picazo; Adriana Becerril-Montes; Delia Huidobro-Perez; Luis M Garcia-Segura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-01
Journal Detail:
Title:  Cellular and molecular neurobiology     Volume:  30     ISSN:  1573-6830     ISO Abbreviation:  Cell. Mol. Neurobiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200709     Medline TA:  Cell Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  675-82     Citation Subset:  IM    
Escuela Superior de Medicina del Instituto Politécnico Nacional, Plan de San Luis y Diaz Mirón Col. Sto. Tomás, 11340 Mexico DF, Mexico.
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MeSH Terms
Cell Count
Cyclodextrins / pharmacology
Dentate Gyrus / cytology,  drug effects,  metabolism
Ethinyl Estradiol / analogs & derivatives,  pharmacology*
Hippocampus / cytology*,  drug effects*,  metabolism
Kainic Acid / pharmacology
Neurons / cytology,  drug effects
Neuroprotective Agents / pharmacology*
Rats, Wistar
Staining and Labeling
Vimentin / metabolism
Reg. No./Substance:
0/Cyclodextrins; 0/Neuroprotective Agents; 0/Vimentin; 487-79-6/Kainic Acid; 57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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