Document Detail

Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.
MedLine Citation:
PMID:  21658409     Owner:  NLM     Status:  Publisher    
α-Synuclein (α-Syn) plays a crucial role in the pathophysiology of Parkinson's disease (PD). α-Syn has been extensively studied in many neuronal cell-based PD models but has yielded mixed results. The objective of this study was to re-evaluate the dual cytotoxic/protective roles of α-Syn in dopaminergic SH-SY5Y cells. Stable SH-SY5Y cells overexpressing wild type or familial α-Syn mutants (A30P, E46K and A53T) were subjected to acute and chronic rotenone and maneb treatment. Compared with untransfected SH-SY5Y cells, wild type α-Syn attenuated rotenone and maneb-induced cell death along with an attenuation of toxin-induced mitochondrial membrane potential changes and Reactive Oxygen Species level, whereas the mutant α-Syn constructs exacerbated environmental toxins-induced cytotoxicity. After chronic treatment, wild type α-Syn but not the mutant variants was found to rescue cells from subsequent acute hydrogen peroxide insult. These results suggest that the fundamental property of wild type α-Syn may be protective, and such property may be lost by its familial PD mutations.
Chi-Jing Choong; Yee-How Say
Related Documents :
22268059 - Pilot in vitro study of the parameters of artificial niche for osteogenic differentiati...
2873869 - Ischemic ca-1 pyramidal cell loss is prevented by preischemic colchicine destruction of...
22271049 - Cellular transfer of magnetic nanoparticles via cell microvesicles: impact on cell trac...
21605699 - Initial steps of metastasis: cell invasion and endothelial transmigration.
11016579 - Color-opponent responses of small and giant bipolar cells in the carp retina.
22161549 - Comparison of nmr lipid profiles in mitotic arrest and apoptosis as indicators of pacli...
20551459 - Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of...
3307899 - Disseminated aspergillosis in a patient with ocular reticulum cell sarcoma.
20974699 - Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-30
Journal Detail:
Title:  Neurotoxicology     Volume:  -     ISSN:  1872-9711     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR) Perak Campus, 31900 Kampar, Perak, Malaysia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interaction between eicosanoids and the complement system in salmonid fish.
Next Document:  Structural remodeling, trafficking and functions of glycosylphosphatidylinositol-anchored proteins.