| Neuroprotection in the newborn infant. | |
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MedLine Citation:
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PMID: 19944839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation, and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells. |
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Authors:
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Fernando F Gonzalez; Donna M Ferriero |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in perinatology Volume: 36 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2010-03-04 Revised Date: 2012-12-10 |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 859-80, vii Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of California, 521 Parnassus Avenue, C215, Box 0663, San Francisco, CA 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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therapeutic use* Brain Injuries / therapy* Humans Hypothermia, Induced / methods* Infant, Newborn Neurogenesis / physiology* Neuroprotective Agents / therapeutic use* Stem Cell Transplantation / methods* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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P50 NS035902/NS/NINDS NIH HHS; P50 NS035902-12/NS/NINDS NIH HHS; R01 NS033997/NS/NINDS NIH HHS; R01 NS033997-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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