Document Detail

Neuroprotection in the newborn infant.
MedLine Citation:
PMID:  19944839     Owner:  NLM     Status:  MEDLINE    
Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation, and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells.
Fernando F Gonzalez; Donna M Ferriero
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  36     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-03-04     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  859-80, vii     Citation Subset:  IM    
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MeSH Terms
Antioxidants / therapeutic use*
Brain Injuries / therapy*
Hypothermia, Induced / methods*
Infant, Newborn
Neurogenesis / physiology*
Neuroprotective Agents / therapeutic use*
Stem Cell Transplantation / methods*
Treatment Outcome
Grant Support
P50 NS035902/NS/NINDS NIH HHS; P50 NS035902-12/NS/NINDS NIH HHS; R01 NS033997/NS/NINDS NIH HHS; R01 NS033997-04/NS/NINDS NIH HHS
Reg. No./Substance:
0/Antioxidants; 0/Neuroprotective Agents

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