| Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. | |
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MedLine Citation:
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PMID: 15894335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mucosal tolerance has been used successfully to treat animal models of autoimmune diseases and is being tested in human diseases. In this work we demonstrate the reduction of infarct size following mucosal tolerance by myelin oligodendrocyte glycoprotein (MOG) (35-55) peptide in mouse stroke model. Nasal MOG was most efficacious and reduced ischemic infarct size by 70% at 24 h as well as improving behavior score. Using immunohistological methods and IL-10 -/- mice, we demonstrate the importance of IL-10-producing CD4+ T cells in the reduction of the ischemic infarct volume following middle cerebral artery occlusion (MCAO). Furthermore, adoptive transfer of CD4+ T cells from nasally tolerized mice to untreated mice prior to MCAO surgery significantly decreased stroke size (p<0.001 vs. control), whereas CD4+ T cells from nasally tolerized IL-10-deficient mice had no significant effect. Based on these results, modulation of cerebral inflammation by mucosal tolerance to myelin antigens may have applicability both as prophylactic therapy and treatment following ischemia attacks. |
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Authors:
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Dan Frenkel; Zhihong Huang; Ruth Maron; Djordje N Koldzic; Michael A Moskowitz; Howard L Weiner |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 233 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-13 Completed Date: 2005-08-22 Revised Date: 2013-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 125-32 Citation Subset: IM |
Affiliation:
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Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Antigens, CD / metabolism Behavior, Animal Brain Infarction / etiology, prevention & control CD4-Positive T-Lymphocytes / drug effects*, physiology Cells, Cultured Cytokines / metabolism Disease Models, Animal Drug Administration Routes Drug Administration Schedule Enzyme-Linked Immunosorbent Assay / methods Female Glycoproteins / administration & dosage* Immune Tolerance / drug effects, physiology Immunohistochemistry / methods Infarction, Middle Cerebral Artery / complications Interleukin-10 / deficiency, metabolism*, therapeutic use* Mice Mice, Inbred C57BL Mice, Knockout Models, Immunological Myelin-Oligodendrocyte Glycoprotein Peptide Fragments / administration & dosage* Severity of Illness Index Stroke / etiology, therapy* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Cytokines; 0/Glycoproteins; 0/Myelin-Oligodendrocyte Glycoprotein; 0/Peptide Fragments; 0/myelin oligodendrocyte glycoprotein (35-55); 130068-27-8/Interleukin-10 |
| Comments/Corrections | |
Erratum In:
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J Neurol Sci. 2013 Mar 15;326(1-2):123 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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