Document Detail

Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke.
MedLine Citation:
PMID:  15894335     Owner:  NLM     Status:  MEDLINE    
Mucosal tolerance has been used successfully to treat animal models of autoimmune diseases and is being tested in human diseases. In this work we demonstrate the reduction of infarct size following mucosal tolerance by myelin oligodendrocyte glycoprotein (MOG) (35-55) peptide in mouse stroke model. Nasal MOG was most efficacious and reduced ischemic infarct size by 70% at 24 h as well as improving behavior score. Using immunohistological methods and IL-10 -/- mice, we demonstrate the importance of IL-10-producing CD4+ T cells in the reduction of the ischemic infarct volume following middle cerebral artery occlusion (MCAO). Furthermore, adoptive transfer of CD4+ T cells from nasally tolerized mice to untreated mice prior to MCAO surgery significantly decreased stroke size (p<0.001 vs. control), whereas CD4+ T cells from nasally tolerized IL-10-deficient mice had no significant effect. Based on these results, modulation of cerebral inflammation by mucosal tolerance to myelin antigens may have applicability both as prophylactic therapy and treatment following ischemia attacks.
Dan Frenkel; Zhihong Huang; Ruth Maron; Djordje N Koldzic; Michael A Moskowitz; Howard L Weiner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  233     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-13     Completed Date:  2005-08-22     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Analysis of Variance
Antigens, CD / metabolism
Behavior, Animal
Brain Infarction / etiology,  prevention & control
CD4-Positive T-Lymphocytes / drug effects*,  physiology
Cells, Cultured
Cytokines / metabolism
Disease Models, Animal
Drug Administration Routes
Drug Administration Schedule
Enzyme-Linked Immunosorbent Assay / methods
Glycoproteins / administration & dosage*
Immune Tolerance / drug effects,  physiology
Immunohistochemistry / methods
Infarction, Middle Cerebral Artery / complications
Interleukin-10 / deficiency,  metabolism*,  therapeutic use*
Mice, Inbred C57BL
Mice, Knockout
Models, Immunological
Myelin-Oligodendrocyte Glycoprotein
Peptide Fragments / administration & dosage*
Severity of Illness Index
Stroke / etiology,  therapy*
Time Factors
Reg. No./Substance:
0/Antigens, CD; 0/Cytokines; 0/Glycoproteins; 0/Myelin-Oligodendrocyte Glycoprotein; 0/Peptide Fragments; 0/myelin oligodendrocyte glycoprotein (35-55); 130068-27-8/Interleukin-10
Erratum In:
J Neurol Sci. 2013 Mar 15;326(1-2):123

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