Document Detail


Neuroprotection: lessons from hibernators.
MedLine Citation:
PMID:  22326449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammals that hibernate experience extreme metabolic states and body temperatures as they transition between euthermia, a state resembling typical warm blooded mammals, and prolonged torpor, a state of suspended animation where the brain receives as low as 10% of normal cerebral blood flow. Transitions into and out of torpor are more physiologically challenging than the extreme metabolic suppression and cold body temperatures of torpor per se. Mammals that hibernate show unprecedented capacities to tolerate cerebral ischemia, a decrease in blood flow to the brain caused by stroke, cardiac arrest or brain trauma. While cerebral ischemia often leads to death or disability in humans and most other mammals, hibernating mammals suffer no ill effects when blood flow to the brain is dramatically decreased during torpor or experimentally induced during euthermia. These animals, as adults, also display rapid and pronounced synaptic flexibility where synapses retract during torpor and rapidly re-emerge upon arousal. A variety of coordinated adaptations contribute to tolerance of cerebral ischemia in these animals. In this review we discuss adaptations in heterothermic mammals that may suggest novel therapeutic targets and strategies to protect the human brain against cerebral ischemic damage and neurodegenerative disease.
Authors:
Kunjan R Dave; Sherri L Christian; Miguel A Perez-Pinzon; Kelly L Drew
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-02-03
Journal Detail:
Title:  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology     Volume:  162     ISSN:  1879-1107     ISO Abbreviation:  Comp. Biochem. Physiol. B, Biochem. Mol. Biol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-23     Completed Date:  2012-09-19     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9516061     Medline TA:  Comp Biochem Physiol B Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Brain Ischemia / physiopathology,  prevention & control
Cerebrovascular Circulation / physiology
Hibernation / physiology*
Humans
Mammals
Neurodegenerative Diseases / physiopathology,  prevention & control
Neuroprotective Agents / pharmacology*,  therapeutic use
Grant Support
ID/Acronym/Agency:
NS041069-06/NS/NINDS NIH HHS; NS054147-01/NS/NINDS NIH HHS; NS34773/NS/NINDS NIH HHS; NS45676-01/NS/NINDS NIH HHS; R01 NS034773/NS/NINDS NIH HHS; R01 NS045676/NS/NINDS NIH HHS; R15 NS070779/NS/NINDS NIH HHS; R15 NS070779-01/NS/NINDS NIH HHS; R15NS070779/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Neuroprotective Agents
Comments/Corrections

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