Document Detail


Neuroplasticity in respiratory motor control.
MedLine Citation:
PMID:  12486024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although recent evidence demonstrates considerable neuroplasticity in the respiratory control system, a comprehensive conceptual framework is lacking. Our goals in this review are to define plasticity (and related neural properties) as it pertains to respiratory control and to discuss potential sites, mechanisms, and known categories of respiratory plasticity. Respiratory plasticity is defined as a persistent change in the neural control system based on prior experience. Plasticity may involve structural and/or functional alterations (most commonly both) and can arise from multiple cellular/synaptic mechanisms at different sites in the respiratory control system. Respiratory neuroplasticity is critically dependent on the establishment of necessary preconditions, the stimulus paradigm, the balance between opposing modulatory systems, age, gender, and genetics. Respiratory plasticity can be induced by hypoxia, hypercapnia, exercise, injury, stress, and pharmacological interventions or conditioning and occurs during development as well as in adults. Developmental plasticity is induced by experiences (e.g., altered respiratory gases) during sensitive developmental periods, thereby altering mature respiratory control. The same experience later in life has little or no effect. In adults, neuromodulation plays a prominent role in several forms of respiratory plasticity. For example, serotonergic modulation is thought to initiate and/or maintain respiratory plasticity following intermittent hypoxia, repeated hypercapnic exercise, spinal sensory denervation, spinal cord injury, and at least some conditioned reflexes. Considerable work is necessary before we fully appreciate the biological significance of respiratory plasticity, its underlying cellular/molecular and network mechanisms, and the potential to harness respiratory plasticity as a therapeutic tool.
Authors:
Gordon S Mitchell; Stephen M Johnson
Related Documents :
7873164 - Defensive reflexes of the respiratory system in anaesthetized rabbits during high frequ...
8066574 - Spontaneous improvement in a patient with the hepatopulmonary syndrome assessed by seri...
11495484 - Performance of heated humidifiers with a heated wire according to ventilatory settings.
6833054 - Coupling of ventilation to pulmonary gas exchange during nonsteady-state work in men.
8181124 - Relation between coronary artery stenosis assessed by visual, caliper, and computer met...
12928584 - Pharmacokinetics of isoflurane: uptake in the brain.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  94     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-17     Completed Date:  2003-06-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-74     Citation Subset:  IM    
Affiliation:
Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA. mitchell@svm.vetmed.wisc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Nervous System Physiological Phenomena
Neuronal Plasticity / physiology*
Respiratory Muscles / innervation*
Respiratory System / innervation*
Grant Support
ID/Acronym/Agency:
HL-53319/HL/NHLBI NIH HHS; HL-65383/HL/NHLBI NIH HHS; HL-69064/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Combined intervention of exercise and genistein prevented androgen deficiency-induced bone loss in m...
Next Document:  Developmental plasticity in respiratory control.