Document Detail

Neurophysiology of limbic system pathways in the rat: projections from the amygdala to the entorhinal cortex.
MedLine Citation:
PMID:  2423179     Owner:  NLM     Status:  MEDLINE    
We studied the responses of rat entorhinal neurons to electrical stimulation of the amygdala. Four main results were obtained: (1) excitatory postsynaptic potentials were recorded in entorhinal neurons in response to electrical stimulation of the amygdala. Cells in layers II, III and V of the entorhinal cortex were responsive. (2) Excitatory responses were followed by inhibitory postsynaptic potentials. (3) Frequency potentiation of both excitatory and inhibitory responses was observed when 10/s stimulation was used. (4) Three amygdala neurons were antidromically activated by entorhinal stimulation; and two layer II entorhinal cells that were excited by amygdala stimulation were also antidromically activated by dentate gyrus stimulation. These results provide evidence for a monosynaptic, excitatory projection from the amygdala to the entorhinal cortex. In addition, the data indicate that amygdala neurons are only one synapse removed from the excitation of dentate gyrus granule cells.
D M Finch; E E Wong; E L Derian; X H Chen; N L Nowlin-Finch; L A Brothers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  370     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-84     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Amygdala / anatomy & histology,  physiology*
Axonal Transport
Cerebral Cortex / anatomy & histology,  physiology*
Efferent Pathways / physiology
Electric Stimulation
Evoked Potentials
Limbic System / anatomy & histology,  physiology*
Neurons / physiology*
Rats, Inbred Strains
Synapses / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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