Document Detail


Neurophysiology of limbic system pathways in the rat: projections from the amygdala to the entorhinal cortex.
MedLine Citation:
PMID:  2423179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the responses of rat entorhinal neurons to electrical stimulation of the amygdala. Four main results were obtained: (1) excitatory postsynaptic potentials were recorded in entorhinal neurons in response to electrical stimulation of the amygdala. Cells in layers II, III and V of the entorhinal cortex were responsive. (2) Excitatory responses were followed by inhibitory postsynaptic potentials. (3) Frequency potentiation of both excitatory and inhibitory responses was observed when 10/s stimulation was used. (4) Three amygdala neurons were antidromically activated by entorhinal stimulation; and two layer II entorhinal cells that were excited by amygdala stimulation were also antidromically activated by dentate gyrus stimulation. These results provide evidence for a monosynaptic, excitatory projection from the amygdala to the entorhinal cortex. In addition, the data indicate that amygdala neurons are only one synapse removed from the excitation of dentate gyrus granule cells.
Authors:
D M Finch; E E Wong; E L Derian; X H Chen; N L Nowlin-Finch; L A Brothers
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  370     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Amygdala / anatomy & histology,  physiology*
Animals
Axonal Transport
Cerebral Cortex / anatomy & histology,  physiology*
Efferent Pathways / physiology
Electric Stimulation
Evoked Potentials
Limbic System / anatomy & histology,  physiology*
Male
Neurons / physiology*
Rats
Rats, Inbred Strains
Synapses / physiology
Grant Support
ID/Acronym/Agency:
NS 16721/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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