Document Detail


Neurophysiological studies in acute transverse myelitis.
MedLine Citation:
PMID:  11200687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A systematic evaluation of anterior horn cell, motor and sensory pathways is possible by electromyography (EMG), motor (MEPs) and somatosensory (SEPs) evoked potentials, respectively, which may provide valuable information on acute transverse myelitis (ATM). In a prospective hospital-based study, EMG, MEP and SEP studies were carried out on admission and after 3 months in 39 patients with ATM. All the patients also underwent detailed clinical evaluation, and spinal magnetic resonance imaging (MRI) was performed in 28. Outcome was defined at the end of 3 months as poor, partial or complete recovery on the basis of functional status. Spinal MRI revealed hyperintense signal changes in T2 extending for two segments to the entire spinal cord. Central motor conduction time to tibialis anterior (CMCT-TA) was more frequently abnormal (90%), followed by tibial SEP (77%). CMCT to abductor digiti minimi (ADM) was abnormal in 30% and median SEP in 15% of patients. Evidence of denervation on EMG was present in 51% of patients. The CMCT-TA improved in 48% patients and tibial SEP in 32%. Median SEP improved in all patients, and CMCT-ADM remained prolonged in two. At 3 months 2 patients had died, and 18 had poor, 10 partial and 9 complete recovery. CMCT was correlated with muscle power, tone, reflex and MRI changes. Patients' outcome of was correlated with CMCT, SEP and EMG. These results are consistent with pronounced involvement of dorsal region of spinal cord in ATM. MEP is more frequently abnormal than SEP.
Authors:
J Kalita; U K Misra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  247     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-31     Completed Date:  2001-03-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  943-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, Sanjay Gandhi PGIMS, Lucknow-226014, India. jkalita@sgpgi.ac.in
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Evoked Potentials, Motor*
Evoked Potentials, Somatosensory*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Myelitis, Transverse / diagnosis*,  physiopathology*
Neural Conduction
Prognosis
Tibial Nerve / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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