| Neurophysiological consequences of nitroxide antioxidants. | |
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MedLine Citation:
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PMID: 7648519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitroxides are antioxidant compounds that have been shown to provide radioprotection in vivo and in vitro. Radioprotection in vivo is limited by toxicity, which appears to be neurologic in nature. To further evaluate the toxicity of these compounds, three representative nitroxides, Tempol, Tempamine, and Tempo, were examined in slices of guinea pig hippocampus. Each nitroxide increased the population spike and caused potentiation of excitatory postsynaptic potential--spike coupling. Repetitive activity and epileptiform activity were observed at the highest concentrations of Tempo and Tempamine. Tempol was the least toxic compound in this system, followed by Tempamine and Tempo. Additional studies are necessary to further define the effects of nitroxides on the central nervous system and to develop strategies to mitigate these effects. |
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Authors:
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S M Hahn; D L Lepinski; A M DeLuca; J B Mitchell; T C Pellmar |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 73 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-09-26 Completed Date: 1995-09-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 399-403 Citation Subset: IM |
Affiliation:
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Radiation Biology Branch, National Cancer Institute, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Cyclic N-Oxides / pharmacology Electrophysiology Epilepsy / chemically induced, physiopathology Evoked Potentials / drug effects Guinea Pigs Hippocampus / cytology*, drug effects Male Microelectrodes Nitrogen Oxides / antagonists & inhibitors* Spin Labels |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Cyclic N-Oxides; 0/Nitrogen Oxides; 0/Spin Labels; 2226-96-2/tempol; 2564-83-2/TEMPO |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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