Document Detail


Neurophysiological evidence of corollary discharge function during vocalization in psychotic patients and their nonpsychotic first-degree relatives.
MedLine Citation:
PMID:  23155183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Predictions about sensations resulting from motor acts are instantiated through neural mechanisms such as the corollary discharge. With each action, the corollary discharge provides an unconscious comparison between predicted and actual sensations resulting from the action; closer matches result in greater suppression of sensation. This mechanism is disrupted in schizophrenia (SZ) and may contribute to, or reflect a failure to, distinguish self- from externally generated experiences, a hallmark of psychosis. We asked whether disruption is specific to SZ or is seen in other psychotic illnesses and in first-degree relatives of psychotic patients. Corollary discharge function was assessed in SZ patients (n = 30), schizoaffective (SA) patients (n = 19), bipolar patients with a history of psychosis (BPP; n = 39), nonpsychotic relatives of SZ (n = 30), SA (n = 23), and BPP (n = 50) patients, and healthy controls (n = 43). The N1 component of the event-related potential, reflecting auditory cortical responses to sounds, was elicited by speech sound onset as subjects talked and later when they listened to a recording of those sounds. N1 was suppressed during talking compared to N1 during listening, consistent with the suppressive action of the corollary discharge mechanism. Suppression was significantly reduced in SZ and BPP patients, with a similar trend in the smaller SA group. Patient groups did not differ, and unaffected relatives did not differ from controls or probands. The failure to monitor sensations resulting from self-generated actions, implicating corollary discharge dysfunction, may be a common feature across affective and nonaffective psychosis. Data from unaffected family members do not indicate that this is a marker of psychosis risk.
Authors:
Judith M Ford; Daniel H Mathalon; Brian J Roach; Sarah K Keedy; James L Reilly; Elliot S Gershon; John A Sweeney
Related Documents :
18568063 - Increased serum interleukin-1beta and interleukin-6 in elderly, chronic schizophrenic p...
21893 - Pretty patient - healthy patient? a study of physical attractiveness and psychopathology.
2670463 - Treatment of hemoptysis patients by thrombin and fibrinogen-thrombin infusion therapy u...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-15
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  39     ISSN:  1745-1701     ISO Abbreviation:  Schizophr Bull     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-14     Completed Date:  2014-06-23     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1272-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Bipolar Disorder / physiopathology*
Brain / physiopathology*
Evoked Potentials, Auditory / physiology*
Family
Female
Humans
Male
Middle Aged
Psychotic Disorders / physiopathology*
Risk
Schizophrenia / physiopathology*
Speech Perception / physiology
Grant Support
ID/Acronym/Agency:
K23 MH092702/MH/NIMH NIH HHS; MH-58262/MH/NIMH NIH HHS; MH077862/MH/NIMH NIH HHS; MH085485/MH/NIMH NIH HHS; R01 MH058262/MH/NIMH NIH HHS; R01 MH077862/MH/NIMH NIH HHS; R01 MH085485/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Variation in psychosis gene ZNF804A is associated with a refined schizotypy phenotype but not neuroc...
Next Document:  Targeted delivery of paclitaxel to EphA2-expressing cancer cells.