| Neurophysins in central diabetes insipidus. | |
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MedLine Citation:
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PMID: 8964580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When they were discovered by Acher and co-workers, neurophysins were thought to act as carriers for the active nonapeptides vasopressin (AVP) and oxytocin (OT) and were then recognized as the inactive fragment of a precursor with a higher molecular weight (propressophysin). The role of neurophysins in the hypothalamo-neurohypophyseal system is now being reconsidered in the light of crystallographic and molecular biology research and the recent definition of the different deletions or substitutions that cause central diabetes insipidus in rats (Brattleboro) or human beings. Apparently, any disruption of the structure and/or conformation of neurophysins (by genic substitution or deletion) may cause a decline in the binding and the activity of the endopeptidase responsible for the cleavage of the AVP. The disruption may also produce a change in the polymerization of neurophysins and salt bridges relating this to the neuropeptides, with the result that there is an accelerated aspecific enzymatic degradation of the hormone revealing clinical symptomatology. So, rather than being a mere inactive part of the precursor, neurophysins are now equally regarded as a system for carrying and protecting nonapeptides. |
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Authors:
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J J Legros; V Geenen |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hormone research Volume: 45 ISSN: 0301-0163 ISO Abbreviation: Horm. Res. Publication Date: 1996 |
Date Detail:
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Created Date: 1996-12-12 Completed Date: 1996-12-12 Revised Date: 2006-11-28 |
Medline Journal Info:
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Nlm Unique ID: 0366126 Medline TA: Horm Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 182-6 Citation Subset: IM |
Affiliation:
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Endocrinology Department, Centre Hospitalier Universitaire-Sart Tilman, Liège, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / genetics, physiology Diabetes Insipidus / physiopathology* Humans Mutation Neurophysins / genetics, physiology* Oxytocin* Protein Precursors / genetics, physiology |
| Chemical | |
Reg. No./Substance:
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0/Neurophysins; 0/Protein Precursors; 113-79-1/Arginine Vasopressin; 50-56-6/Oxytocin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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