Document Detail


Neuropharmacology of Sleep and Wakefulness: 2012 Update.
MedLine Citation:
PMID:  23162386     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This chapter reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.
Authors:
Christopher J Watson; Helen A Baghdoyan; Ralph Lydic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-4
Journal Detail:
Title:  Sleep medicine clinics     Volume:  7     ISSN:  1556-4088     ISO Abbreviation:  Sleep Med Clin     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271531     Medline TA:  Sleep Med Clin     Country:  -    
Other Details:
Languages:  ENG     Pagination:  469-486     Citation Subset:  -    
Affiliation:
Department of Anesthesiology, University of Michigan, Ann Arbor, MI, U.S.A.
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