| Neuropharmacology of 5-hydroxytryptamine. | |
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MedLine Citation:
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PMID: 16402098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review outlines the history of our knowledge of the neuropharmacology of 5-hydroxytryptamine (5-HT; serotonin), focusing primarily on the work of U.K. scientists. The existence of a vasoconstrictive substance in the blood has been known for over 135 years. The substance was named serotonin and finally identified as 5-HT in 1949. The presence of 5-HT in the brain was reported by Gaddum in 1954 and it was Gaddum who also demonstrated that the action of 5-HT (in the gut) was antagonised by the potent hallucinogen lysergic acid diethylamide. This provoked the notion that 5-HT played a pivotal role in the control of mood and subsequent investigations have generally confirmed this hypothesis. Over the last 50 years a good understanding has been gained of the mechanisms involved in control of the storage, synthesis and degradation of 5-HT in the brain. Knowledge has also been gained on control of the functional activity of this monoamine, often by the use of behavioural models. A considerable literature also now exists on the mechanisms by which many of the drugs used to treat psychiatric illness alter the functional activity of 5-HT, particularly the drugs used to treat depression. Over the last 20 years the number of identified 5-HT receptor subtypes has increased from 2 to 14, or possibly more. A major challenge now is to utilise this knowledge to develop receptor-specific drugs and use the information gained to better treat central nervous system disorders. |
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Authors:
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A Richard Green |
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Publication Detail:
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Type: Historical Article; Journal Article; Portraits |
Journal Detail:
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Title: British journal of pharmacology Volume: 147 Suppl 1 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-10 Completed Date: 2006-12-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: S145-52 Citation Subset: IM |
Affiliation:
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Global Discovery CNS and Pain Control, AstraZeneca R and D Charnwood, Bakewell Road, Loughborough LE11 5RH. richard.green@astrazeneca.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antidepressive Agents / therapeutic use Brain / drug effects, physiology* Great Britain History, 20th Century History, 21st Century Humans Receptors, Serotonin / drug effects, history, physiology Serotonin / history*, physiology Serotonin Agents / history, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Receptors, Serotonin; 0/Serotonin Agents; 50-67-9/Serotonin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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