Document Detail

Neuropharmacological evidence to suggest that the nucleus accumbens and subpallidal region contribute to exploratory locomotion.
MedLine Citation:
PMID:  6508693     Owner:  NLM     Status:  MEDLINE    
Rats showed a substantial increase in locomotor activity when novel objects were introduced into an open-field apparatus. This exploratory locomotion was reduced significantly when glutamic acid diethyl ester HCl, a glutamate antagonist, was injected bilaterally into the nucleus accumbens or when gamma-aminobutyric acid was injected bilaterally into the subpallidal region. These observations provide preliminary support for a contribution of the nucleus accumbens and subpallidal region to exploratory locomotion.
G J Mogenson; M Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral and neural biology     Volume:  42     ISSN:  0163-1047     ISO Abbreviation:  Behav. Neural Biol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905471     Medline TA:  Behav Neural Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  52-60     Citation Subset:  IM    
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MeSH Terms
Exploratory Behavior / drug effects*
Globus Pallidus / drug effects*
Glutamates / pharmacology*
Motor Activity / drug effects*
Neural Pathways / drug effects
Nucleus Accumbens / drug effects*
Rats, Inbred Strains
Septal Nuclei / drug effects*
gamma-Aminobutyric Acid / pharmacology*
Reg. No./Substance:
0/Glutamates; 16450-41-2/glutamic acid diethyl ester; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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