Document Detail

Neuropeptides in the cerebrospinal fluid (CSF) in psychiatric disorders.
MedLine Citation:
PMID:  3937176     Owner:  NLM     Status:  MEDLINE    
Concentrations of vasoactive intestinal polypeptide (VIP), cholecystokinin (CCK) and gastrin in the cerebrospinal fluid (CSF) was studied in patients with endogenous depression, non-endogenous depression, mania, schizophrenia and a control group. All patients were classified according to various diagnostic systems. In the group of non-endogenously depressed patients CSF-VIP levels (median 16 pmol/l) were found significantly lowered compared to controls (median = 32 pmol/l) and endogenous depression (26 pmol/l). Going through the non-endogenous group it appeared that the low CSF-VIP was due to a group of patients with a former diagnosis of endogenous depression or a present diagnosis of possible endogenous depression. Moreover, this group was clinically characterized by 'dysphoric/hysterical features', 'reversed diurnal variation' (i.e. worst in the evening), and 'lack of clearly circumscribed episode'. In many aspects this group seems similar to the atypical depressions described as monoamineoxidase responders. Concerning CSF-CCK and CSF-gastrin no significant differences between the examined groups were demonstrated.
O J Rafaelsen; A Gjerris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  9     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-18     Completed Date:  1986-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  IM    
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MeSH Terms
Arginine Vasopressin / cerebrospinal fluid
Cholecystokinin / cerebrospinal fluid
Depressive Disorder / cerebrospinal fluid
Mental Disorders / cerebrospinal fluid*
Middle Aged
Nerve Tissue Proteins / cerebrospinal fluid*
Schizophrenia / cerebrospinal fluid
Thyrotropin-Releasing Hormone / cerebrospinal fluid
Vasoactive Intestinal Peptide / cerebrospinal fluid
Reg. No./Substance:
0/Nerve Tissue Proteins; 113-79-1/Arginine Vasopressin; 24305-27-9/Thyrotropin-Releasing Hormone; 37221-79-7/Vasoactive Intestinal Peptide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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