| Neuropeptides in the cerebrospinal fluid (CSF) in psychiatric disorders. | |
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MedLine Citation:
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PMID: 3937176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concentrations of vasoactive intestinal polypeptide (VIP), cholecystokinin (CCK) and gastrin in the cerebrospinal fluid (CSF) was studied in patients with endogenous depression, non-endogenous depression, mania, schizophrenia and a control group. All patients were classified according to various diagnostic systems. In the group of non-endogenously depressed patients CSF-VIP levels (median 16 pmol/l) were found significantly lowered compared to controls (median = 32 pmol/l) and endogenous depression (26 pmol/l). Going through the non-endogenous group it appeared that the low CSF-VIP was due to a group of patients with a former diagnosis of endogenous depression or a present diagnosis of possible endogenous depression. Moreover, this group was clinically characterized by 'dysphoric/hysterical features', 'reversed diurnal variation' (i.e. worst in the evening), and 'lack of clearly circumscribed episode'. In many aspects this group seems similar to the atypical depressions described as monoamineoxidase responders. Concerning CSF-CCK and CSF-gastrin no significant differences between the examined groups were demonstrated. |
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Authors:
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O J Rafaelsen; A Gjerris |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 9 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 1985 |
Date Detail:
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Created Date: 1986-03-18 Completed Date: 1986-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 533-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arginine Vasopressin / cerebrospinal fluid Cholecystokinin / cerebrospinal fluid Depressive Disorder / cerebrospinal fluid Female Humans Male Mental Disorders / cerebrospinal fluid* Middle Aged Nerve Tissue Proteins / cerebrospinal fluid* Schizophrenia / cerebrospinal fluid Thyrotropin-Releasing Hormone / cerebrospinal fluid Vasoactive Intestinal Peptide / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 113-79-1/Arginine Vasopressin; 24305-27-9/Thyrotropin-Releasing Hormone; 37221-79-7/Vasoactive Intestinal Peptide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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