Document Detail

Neuropeptides, food intake and body weight regulation: a hypothalamic focus.
MedLine Citation:
PMID:  12535710     Owner:  NLM     Status:  MEDLINE    
Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redundant) controlling system. Starvation as well as overfeeding lead to changes in expression levels of these neuropeptides, which act downstream of leptin, resulting in a physiological response. In this review the role of several anorexigenic and orexigenic (hypothalamic) neuropeptides on food intake and body weight regulation is summarized.
J J G Hillebrand; D de Wied; R A H Adan
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Peptides     Volume:  23     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-21     Completed Date:  2003-08-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2283-306     Citation Subset:  IM    
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
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MeSH Terms
Body Weight / physiology*
Eating / physiology*
Homeostasis / physiology
Hypothalamus / physiology*
Insulin / physiology
Leptin / physiology
Neurons / physiology
Neuropeptides / physiology*
Reg. No./Substance:
0/Leptin; 0/Neuropeptides; 11061-68-0/Insulin

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