| Neuropeptide signaling systems - potential drug targets for parasite and pest control. | |
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MedLine Citation:
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PMID: 12052188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current problems of drug resistance in parasites and pests demand the identification of new targets and their exploitation through novel drug design and development programs. Neuropeptide signaling systems in helminths (nematodes and platyhelminths = worms) and arthropods are well developed and complex, play a crucial role in many aspects of their biology, and appear to have significant potential as targets for novel drugs. The best-known neuropeptide family in invertebrates is the FMRFamide-related peptides (FaRPs). Amongst many roles, FaRPs potently influence motor function. The genome sequencing projects of Drosophila melanogaster and Caenorhabditis elegans have revealed unexpected complexity within the FaRPergic systems of arthropods and nematodes, although available evidence for platyhelminths indicates structural and functional simplicity. Regardless of these differences, FaRPs potently modulate motor function in arthropods, nematodes and platyhelminths and there appears to be at least some commonality in the FaRPergic signaling systems therein. Moreover, there is now increasing evidence of cross-phyla activity for individual FaRPs, providing clear signals of opportunities for target selection and the identification and development of broad-spectrum drugs. |
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Authors:
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Aaron G Maule; Angela Mousley; Nikki J Marks; Tim A Day; David P Thompson; Timothy G Geary; David W Halton |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current topics in medicinal chemistry Volume: 2 ISSN: 1568-0266 ISO Abbreviation: Curr Top Med Chem Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-06-07 Completed Date: 2003-08-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 101119673 Medline TA: Curr Top Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 733-58 Citation Subset: IM |
Affiliation:
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Parasitology Research Group, School of Biology and Biochemistry, Queen' s University Belfast, Belfast BT9 7BL, UK. a.maule@qub.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antiparasitic Agents / pharmacology, therapeutic use* Arthropods / drug effects Drug Delivery Systems Helminths / drug effects Neuropeptides / chemical synthesis, pharmacology, therapeutic use* Parasites / drug effects* Parasitic Diseases, Animal / drug therapy*, prevention & control Signal Transduction Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Antiparasitic Agents; 0/Neuropeptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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