Document Detail

Neuropeptide changes in a primate model (Cebus apella) for tardive dyskinesia.
MedLine Citation:
PMID:  1723515     Owner:  NLM     Status:  MEDLINE    
Tardive dyskinesia has been connected with regional reductions of GABA functions in the basal ganglia. In view of the possibility that peptides are involved in neuroleptic-induced dyskinesias substance P and dynorphin A levels were measured in the basal ganglia of the Cebus apella model for tardive dyskinesia. In addition, regional glutamate decarboxylase activities, dopamine, homovanillic acid and dihydroxyphenylacetic acid levels were monitored. A significant dyskinesia-related decrease in glutamate decarboxylase activity was found in the subthalamic nucleus, the medial segment of globus pallidus and the rostral part of substantia nigra in accordance with earlier findings. Cebus monkeys with an intact GABA system (neuroleptic-treated controls without dyskinesia) showed increased levels of substance P and homovanillic acid in the caudate nucleus. The changes were confined to the caudal part of the body of the caudate and the nucleus accumbens. On the other hand, the dyskinetic monkeys, with a defective GABA system, did not demonstrate a similar substance P rise in the caudate or nucleus accumbens, but showed a depression of homovanillic acid levels in the caudal part of the body of the caudate nucleus. Dynorphin A, dopamine and dihydroxyphenylacetic acid showed no dyskinesia-related changes. In conclusion, the difference in glutamate decarboxylase activity between animals developing dyskinetic symptoms vs those who did not, was reflected by regional changes in substance P and homovanillic acid levels.
P E Johansson; L Terenius; J E Häggström; L Gunne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  37     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1990  
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  IM    
Department of Psychiatry at Ulleräker, University of Uppsala, Sweden.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Behavior, Animal / drug effects
Brain Chemistry
Corpus Striatum / metabolism
Disease Models, Animal
Dynorphins / metabolism
Dyskinesia, Drug-Induced / metabolism*
Globus Pallidus / metabolism
Glutamate Decarboxylase / metabolism
Homovanillic Acid / metabolism
Neuropeptides / metabolism*
Substance P / metabolism
Substantia Nigra / metabolism
Reg. No./Substance:
0/Neuropeptides; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 33507-63-0/Substance P; 74913-18-1/Dynorphins; EC Decarboxylase

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