| Neuropeptide Y: the universal soldier. | |
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MedLine Citation:
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PMID: 12678499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The peptidic neuropeptide Y (NPY) has received great attention because it has been implicated in the regulation of several organ systems. In particular, NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. Furthermore, NPY exerts vasoconstrictive action on the vasculature and potentiates the actions of many other vasoconstrictors. In addition, it was demonstrated to have trophic properties and could therefore contribute to cardiovascular remodeling. These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure. |
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Authors:
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T Pedrazzini; F Pralong; E Grouzmann |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 60 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-04-07 Completed Date: 2003-04-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 350-77 Citation Subset: IM |
Affiliation:
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Division of Hypertension, University of Lausanne Medical School, 1011 Lausanne, Switzerland. thierry.pedrazzini@chuv.hospvd.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / therapeutic use Appetite Stimulants / therapeutic use Cardiovascular Diseases / drug therapy Cardiovascular System / metabolism Forecasting Humans Hypothalamus / metabolism Models, Biological Neuropeptide Y / metabolism*, therapeutic use Neurosecretory Systems / metabolism Protein Processing, Post-Translational Receptors, Neuropeptide Y / genetics, metabolism* Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Appetite Stimulants; 0/Neuropeptide Y; 0/Receptors, Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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