Document Detail

Neuropeptide Y: the universal soldier.
MedLine Citation:
PMID:  12678499     Owner:  NLM     Status:  MEDLINE    
The peptidic neuropeptide Y (NPY) has received great attention because it has been implicated in the regulation of several organ systems. In particular, NPY is involved in the regulatory loops that control food intake in the hypothalamus and appears also to be important for regulating the activity of neuroendocrine axes under poor metabolic conditions. Furthermore, NPY exerts vasoconstrictive action on the vasculature and potentiates the actions of many other vasoconstrictors. In addition, it was demonstrated to have trophic properties and could therefore contribute to cardiovascular remodeling. These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure.
T Pedrazzini; F Pralong; E Grouzmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  60     ISSN:  1420-682X     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-07     Completed Date:  2003-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  350-77     Citation Subset:  IM    
Division of Hypertension, University of Lausanne Medical School, 1011 Lausanne, Switzerland.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Appetite Stimulants / therapeutic use
Cardiovascular Diseases / drug therapy
Cardiovascular System / metabolism
Hypothalamus / metabolism
Models, Biological
Neuropeptide Y / metabolism*,  therapeutic use
Neurosecretory Systems / metabolism
Protein Processing, Post-Translational
Receptors, Neuropeptide Y / genetics,  metabolism*
Signal Transduction
Reg. No./Substance:
0/Antihypertensive Agents; 0/Appetite Stimulants; 0/Neuropeptide Y; 0/Receptors, Neuropeptide Y

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