| Neuropeptide Y and sympathetic control of heart contractility and coronary vascular tone. | |
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MedLine Citation:
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PMID: 3840319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of neuropeptide Y (NPY) on contractility of the spontaneously beating guinea-pig atrium and transmural nerve stimulation (TNS)-induced efflux of tritium-noradrenaline (3H-NA) were studied in vitro. NPY induced a moderate positive chronotropic and inotropic atrial response, which was resistant to metoprolol. TNS at 2 Hz for 2 s caused an increase in rate and contractile force. These effects were significantly reduced by NPY. NPY also reduced the TNS induced (2 Hz for 20 s), fractional [3H]NA release by 40% without affecting the contractile response. The contractile effects of exogenous NA on the guinea-pig atrium were not affected by NPY. NPY caused a long-lasting increase in coronary perfusion pressure, and also, in high doses, an inhibition of ventricular contractility in the isolated, perfused guinea-pig heart. The perfusion pressure increase to NPY, which most likely reflects coronary vasoconstriction, was resistant to alpha- and beta-adrenoceptor blockade but sensitive to the calcium antagonist nifedipine. A 50% reduction of the vascular NPY response occurred at 10(-9) M nifedipine, which did not influence cardiac contractility per se or the contractile effects of NA. NPY did not modify the increase in ventricular contractility induced by NA. Noradrenaline did not influence coronary perfusion pressure after beta-blockade. Since NPY is present together with NA in cardiac nerves, it may be suggested that NPY is involved in the regulation of NA release as well as the sympathetic control of atrial contractility and coronary blood flow. |
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Authors:
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A Franco-Cereceda; J M Lundberg; C Dahlöf |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 124 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1985 Jul |
Date Detail:
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Created Date: 1985-11-21 Completed Date: 1985-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 361-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / pharmacology Atropine / pharmacology Coronary Vessels / drug effects* Electric Stimulation Guinea Pigs Male Metoprolol / pharmacology Muscle, Smooth, Vascular / drug effects Myocardial Contraction / drug effects* Nerve Tissue Proteins / pharmacology* Neuropeptide Y Nifedipine / pharmacology Norepinephrine / pharmacology Phentolamine / pharmacology Tetrodotoxin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 0/Neuropeptide Y; 113-79-1/Arginine Vasopressin; 21829-25-4/Nifedipine; 37350-58-6/Metoprolol; 4368-28-9/Tetrodotoxin; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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