Document Detail

Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus.
MedLine Citation:
PMID:  6549039     Owner:  NLM     Status:  MEDLINE    
Neuropeptide Y (NPY), a peptide contained within numerous presynaptic terminals in the hypothalamic paraventricular nucleus (PVN), was injected directly into the PVN of satiated, brain-cannulated rats, and food and water intake were measured 0.5, 1, 2 and 4 hrs postinjection. Neuropeptide Y (24 and 78 pmoles/0.3 microliter isotonic saline) caused a dose-dependent increase in food intake, as well as a small, dose-dependent increase in water intake. This effect on feeding occurred even when food was not presented until 4 hrs postinjection. To determine the behavioral specificity of this effect, the impact of PVN injection of NPY (78 pmoles) on various behaviors was observed. With food available, only feeding and drinking behavior were affected. No change in other behaviors, including grooming, rearing, sleeping, resting or different levels of activity, was observed. With food absent, NPY still elicited drinking, suggesting that this is a primary effect, rather than secondary to the feeding. In addition to drinking, NPY reliably increased activity while decreasing sleep and grooming. These results suggest an important role for hypothalamic NPY, or a structurally-related peptide, in the regulation of feeding and drinking behavior.
B G Stanley; S F Leibowitz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  35     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-31     Completed Date:  1985-01-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2635-42     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal / drug effects
Dose-Response Relationship, Drug
Drinking / drug effects*
Eating / drug effects*
Grooming / drug effects
Injections, Intraventricular
Nerve Tissue Proteins / pharmacology*
Neuropeptide Y
Paraventricular Hypothalamic Nucleus / drug effects*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neuropeptide Y

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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