Document Detail

Neuropeptide Y stimulates food consumption through multiple receptors in goldfish.
MedLine Citation:
PMID:  11564467     Owner:  NLM     Status:  MEDLINE    
In this study, the acute effects of brain intracerebroventricular (icv) injections of mammalian neuropeptide Y (NPY) Y1 ([31Leu,34Pro]NPY), Y2 (NPY2-36) and Y5 ([D-32Trp]NPY) receptor subtype agonists on food intake in goldfish were examined. Icv injection of Y1 and Y5 receptor agonists in dosages of 1 and 5 ng/g exhibited dose-dependent effects on food intake; however, higher dosages of both receptor subtypes had desensitising effects on food intake, and caused a decrease in food intake in comparison to the lower dosages. At 10 and 20 ng/g, Y1 receptor agonist-treated fish exhibited feeding significantly lower than intact and saline-injected fish; fish treated with the same dosages of Y5 agonist exhibited food intake similar to intact and saline-injected fish. Y2 agonist had no effects on food intake. Co-icv administration of Y1 and Y5 agonists in dosages of 1 and 5 ng/g caused enhanced food intake that was additive of the individual doses alone. However, desensitising one receptor did not influence the responsiveness of the other. Co-icv injection of Y1 receptor agonist in desensitizing high dosages (10 and 15 ng/g) with Y5 receptor agonist in lower doses (1 and 5 ng/g, respectively) or vice versa, resulted in a food intake similar to the dosages of Y1 and Y5 receptor agonists at 1 and 5 ng/g given alone. Overall, this study demonstrates that NPY acts centrally through Y1 and Y5 receptors to stimulate food intake in goldfish. The Y1 and Y5 receptors appear to act independently in the stimulation of food intake in goldfish.
Y K Narnaware; R E Peter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  74     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:    2001 Sep 1-15
Date Detail:
Created Date:  2001-09-20     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM    
Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
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MeSH Terms
Eating / drug effects*
Goldfish / physiology*
Indicators and Reagents
Injections, Intraventricular
Neuropeptide Y / administration & dosage,  pharmacology*
Receptors, Neuropeptide Y / drug effects*
Stimulation, Chemical
Reg. No./Substance:
0/Indicators and Reagents; 0/Neuropeptide Y; 0/Receptors, Neuropeptide Y

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