Document Detail


Neuropeptide Y-related compounds and feeding.
MedLine Citation:
PMID:  10073499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropeptide Y (NPY) and related compounds increase short-term feeding. Previous studies have used different animal models, feeding schedules, sources of the compounds, and time and routes of administration. These differences in methodology are important in the variability reported on the potency of NPY-related compounds. To obtain reliable data on the relative efficacy, we tested NPY, NPY 3-36, and pancreatic polypeptide (PP) using an identical protocol and the same commercial source. These three NPY-related compounds were tested using the intracerebroventricular (i.c.v., into the third ventricle) administration, and the profile of the feeding enhancement including the dose response and potency was determined. Compounds were tested in parallel on at least 2 successive days. NPY, NPY 3-36, and PP exhibited different potencies in enhancing 2-h food intake. Comparison of their dose responses (using 0.1, 0.25, 0.5, 1.0, 2.5, and 5.0 microg/rat) demonstrated an overall potency of NPY 3-36 > NPY > PP for the high doses. To study ligand interactions, we examined the effects of various combinations of NPY-related compounds administered concomitantly. These combinations were justified based on the data obtained from the individual dose responses. The data show that the effects of NPY plus NPY 3-36 or NPY 3-36 plus PP were less than additive. When compared to the individual responses, the effects of NPY 3-36 were almost identical to those induced by the combinations using low doses of NPY plus NPY 3-36, or low and high doses of PP plus NPY 3-36. The results support the notion that NPY and its analogues induce a short-term feeding response by activating multiple receptor subtypes.
Authors:
M C Flynn; C R Plata-Salamán; J M Ffrench-Mullen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  65     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:    1999 Jan 1-15
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  901-5     Citation Subset:  IM    
Affiliation:
Division of Molecular Biology, School of Life and Health Sciences, University of Delaware, Newark 19716-2590, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Stimulants / pharmacology*
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Injections, Intraventricular
Male
Neuropeptide Y / analogs & derivatives*,  pharmacology*
Pancreatic Polypeptide / pharmacology
Peptide Fragments / pharmacology
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Appetite Stimulants; 0/Neuropeptide Y; 0/Peptide Fragments; 0/neuropeptide Y (3-36); 59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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