| Neuropeptide Y receptor Y2 gene polymorphism interacts with plasma neuropeptide Y levels in predicting left ventricular hypertrophy in dialysis patients. | |
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MedLine Citation:
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PMID: 20543711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Neuropeptide Y (NPY) is a sympathetic neurotransmitter that acts on multiple receptors involved in cardiovascular remodelling and angiogenesis. Plasma levels of NPY are increased in patients with end-stage renal disease (ESRD) and are independently related to left ventricular hypertrophy (LVH) and incident cardiovascular events in these patients. OBJECTIVE: To investigate the relationship between NPY receptor Y2 gene polymorphism and left ventricular mass index (LVMI) as well as the interaction between this polymorphism and plasma NPY in determining LVH in 189 ESRD patients. RESULTS: LVMI was significantly higher (+12%, P = 0.03) in patients carrying the C allele than in those without C allele and was linearly associated with plasma NPY (P = 0.01). Interaction analysis showed a significant NPY-LVMI relationship in patients with the C allele, both at univariate (r = 0.27, P = 0.001) and multivariate (r = 0.21, P = 0.01) analyses, whereas no such relationship existed in patients without this allele. In fully adjusted analyses, a 10 pmol/l increase in plasma NPY entailed a 4.9 g/m increase in LVMI in patients with C allele, whereas the same change in NPY levels did not modify the NPY-LVMI link in patients without such allele (P = 0.009). CONCLUSION: NPY receptor Y2 polymorphism is independently associated with LVMI and interacts with plasma levels of NPY in explaining the variability of LVH in ESRD. These results offer a genetic basis to the hypothesis that NPY is causally implicated in the pathogenetic pathway leading to LVH in ESRD patients. |
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Authors:
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Alessandra Testa; Francesca Mallamaci; Roberta Macrì; Anna Pisano; Belinda Spoto; Lorenzo S Malatino; Benedetta Stancanelli; Giovanni Tripepi; Francesco A Benedetto; Carmine Zoccali |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-21 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1745-51 Citation Subset: IM |
Affiliation:
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CNR-IBIM, National Research Council, Institute of Biomedicine, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Comorbidity Female Genetic Predisposition to Disease* Humans Hypertrophy, Left Ventricular / epidemiology, genetics*, pathology Italy / epidemiology Kidney Failure, Chronic / epidemiology, genetics*, pathology Logistic Models Male Middle Aged Neuropeptide Y / blood* Polymorphism, Single Nucleotide* Receptors, Neuropeptide Y / genetics* Renal Dialysis |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y2 receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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