| Neuropeptide Y polymorphisms and ischemic stroke in Chinese population. | |
| | |
MedLine Citation:
|
PMID: 19913525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Stroke is the second most common cause of death in developed countries and a major cause of adult disability and mortality worldwide. New data strongly suggest that neuropeptide Y (NPY) may be a candidate gene for ischemic stroke. METHODS: We investigated 450 ischemic stroke patients and 423 healthy controls matched for sex and age in a Han Chinese population. Three functional polymorphisms (-883TGins/del, -602G/T and -399 T/C) located in NPY gene promoter were genotyped using DNA sequencing methods. RESULTS: Of 3 NPY polymorphisms investigated in our study, the -399CC genotype (OR: 1.699, 95% CI: 1.124-2.567, P=0.011) and the -399C allele (OR: 1.254, 95% CI: 1.031-1.524, P=0.023) were more frequent among ischemic stroke patients than in controls, especially in the small vessel disease (SVD) subtype patients. The similar results were observed in multivariable logistic regression analysis. Haplotype analysis revealed that the -883ins/-399C haplotype was a risk marker for ischemic stroke (P=0.008). CONCLUSIONS: The C allele of -399 T/C polymorphism in the promoter regions of NPY is an independent risk factor for ischemic stroke, suggesting that NYP system may involve in the mechanisms of stroke pathology. |
| | |
Authors:
|
Jin-Tai Yu; Nan-Nan Yu; Si-Shan Gao; Jing-Hui Song; Teng Ma; Nai-Dong Wang; Yong-Chun Tang; Na Zhang; Lan Tan |
Related Documents
:
|
17851835 - Interleukin-18 gene promoter polymorphisms and the risk of esophageal squamous cell car... 20606025 - The effect of genetic variants in serping1 on the risk of neovascular age-related macul... 20339375 - Polymorphisms in cyp11b2 and cyp11b1 genes associated with primary hyperaldosteronism. 14991745 - Intronic polymorphism (1541-1542delgt) of the constitutive heat shock protein 70 gene h... 14740875 - Prediction of plasmodium falciparum resistance to sulfadoxine/pyrimethamine in vivo by ... 7483675 - Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in h... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-12 |
Journal Detail:
|
Title: Clinica chimica acta; international journal of clinical chemistry Volume: 411 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-27 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 242-5 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, Shandong Province 266071, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Asian Continental Ancestry Group / genetics* Brain Ischemia / complications*, genetics* Case-Control Studies Female Gene Frequency Haplotypes Humans Logistic Models Male Neuropeptide Y / genetics* Polymorphism, Genetic* Stroke / complications*, genetics* |
| Chemical | |
Reg. No./Substance:
|
0/Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Apoptosis Induction in Human Leukemic Cells by a Novel Protein Bengalin, Isolated from Indian Black ...
Next Document: Use of Error Grid Analysis to Evaluate Acceptability of a Point of Care Prothrombin Time Meter.