| Neuropeptide Y paradoxically increases food intake yet causes conditioned flavor aversions. | |
| | |
MedLine Citation:
|
PMID: 1641427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Neuropeptides have been implicated in the short-term regulation of food intake and the long-term control of body weight. Previous studies have shown that central administration of neuropeptide Y (NPY), the most abundant of these peptides in the brain, produces robust increases of food intake. We now report that NPY, at doses that stimulate food intake when administered intraventricularly, also causes the formation of robust conditioned flavor aversions when given via the same cannula and at the same dose. This apparently paradoxical effect may be indicative of different populations of central NPY receptors having dissimilar effects on ingestive behaviors. The results also suggest that the use of conditioned aversions to investigate drug-induced malaise may not be appropriate when applied to ingestive behaviors. |
| | |
Authors:
|
A J Sipols; D J Brief; K L Ginter; S Saghafi; S C Woods |
Related Documents
:
|
11238747 - Glucagon-like peptide 2: a nutrient-responsive gut growth factor. 19906817 - Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity vi... 17192477 - Role for mitochondrial reactive oxygen species in brain lipid sensing: redox regulation... 14672247 - Ghrelin and leptin responses to food ingestion in bulimia nervosa: implications for bin... 18803097 - Wrist strength is dependent on simultaneous power grip intensity. 22763857 - Food safety: at the center of a one health approach for combating zoonoses. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Physiology & behavior Volume: 51 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1992 Jun |
Date Detail:
|
Created Date: 1992-08-28 Completed Date: 1992-08-28 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1257-60 Citation Subset: IM |
Affiliation:
|
Department of Psychology, University of Washington, Seattle 98195. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Conditioning, Operant / drug effects* Eating / drug effects* Injections, Intraventricular Male Neuropeptide Y / pharmacology* Rats Taste / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
|
AA 07455/AA/NIAAA NIH HHS; AM 17844/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mimicking corticosterone's daily rhythm with specific receptor agonists: effects on food, water, and...
Next Document: A possible genetic association between PROP-tasting and alcoholism.