| Neuropeptide Y levels in central and peripheral cerebrospinal fluid in patients with intracranial disorders. | |
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MedLine Citation:
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PMID: 1776515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropeptide Y (NPY) was measured in central and peripheral cerebrospinal fluid (CSF) in patients suffering from various intracranial disorders. The central NPY-like immunoreactivity (LI) level showed a concentration of 129 +/- 19 pmol.l-1 and was significantly increased (p less than 0.05) compared to peripheral CSF (73 +/- 9 pmol.l-1). From five patients with subarachnoid haemorrhage the CSF NPY-LI levels reached 154 +/- 47 pmol.l-1. In five patients peripheral and central CSF was collected at the same occasion and the CSF NPY-LI concentration was 76 +/- 17 pmol.l-1 in peripheral and 142 +/- 23 pmol.l-1 in central CSF (p less than 0.01), respectively. In a reference group of 9 patients, who were examined by lumbar myelography because of suspected intervertebral herniated discs, the peripheral CSF NPY-LI concentration was 59 +/- 5 pmol.l-1 a value which was also significantly lower compared to NPY-LI levels in central CSF. Thus it is obvious that NPY is present in human CSF with a relatively higher concentration in central than in peripheral CSF at least in patients with disorders of the central nervous system, suggesting a central origin of the NPY. |
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Authors:
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H von Holst; A Rudehill; J M Lundberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurochirurgica Volume: 112 ISSN: 0001-6268 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 1991 |
Date Detail:
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Created Date: 1992-03-04 Completed Date: 1992-03-04 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 132-5 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Diseases
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cerebrospinal fluid* Brain Neoplasms / cerebrospinal fluid Humans Intervertebral Disk Displacement / cerebrospinal fluid Neuropeptide Y / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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