Document Detail


Neuropeptide Y, left ventricular mass and function in patients with end stage renal disease.
MedLine Citation:
PMID:  12817184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Neuropeptide Y (NPY) is released during sympathetic stimulation and mediates the central effects of the adipostatic hormone leptin. The plasma concentration of NPY and leptin is increased in patients with end stage renal disease (ESRD), but it is unknown whether these substances are related to biochemical markers of sympathetic activity and to alterations in left ventricular (LV) mass and function in these patients. DESIGN: We investigated the relationship between NPY, norepinephrine (NE), leptin and echocardiographic measurements in a cross-sectional study in 198 patients with ESRD. RESULTS: NPY was directly related to plasma NE and heart rate but it was largely independent of arterial pressure and of retention of metabolic waste products. NPY was significantly higher in patients with LV hypertrophy and in those with LV systolic dysfunction than in those without these alterations. Of note, NPY emerged as an independent correlate of LV mass index and of LV ejection fraction (LVEF) (both P <or= 0.002) in multiple linear regression analyses including a series of cardiovascular risk factors. Furthermore in a multiple logistic regression model patients in the top NPY tertile had a risk for LV concentric hypertrophy that was 18.10 (95% confidence interval: 5.87-55.83) times higher than in those in the first tertile (P < 0.001). Leptin was unrelated to NPY as well as to LV mass and to systolic function. CONCLUSIONS: Elevated NPY is independently associated with LV concentric hypertrophy and systolic dysfunction in ESRD. It remains to be seen whether these links contribute to the high cardiovascular mortality in these patients.
Authors:
Carmine Zoccali; Francesca Mallamaci; Giovanni Tripepi; Francesco A Benedetto; Saverio Parlongo; Sebastiano Cutrupi; Graziella Bonanno; Francesco Rapisarda; Pasquale Fatuzzo; Giuseppe Seminara; Alessandro Cataliotti; Lorenzo S Malatino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  21     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-20     Completed Date:  2004-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1355-62     Citation Subset:  IM    
Affiliation:
CNR, Institute of Biomedicine, Epidemiology and Pathophysiology of Renal Diseases and Hypertension and Division of Nephrology, Morelli Hospital, Reggio Calabria, Italy. carmine.zoccali@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers
Cohort Studies
Cross-Sectional Studies
Echocardiography
Female
Humans
Hypertrophy, Left Ventricular / epidemiology,  metabolism*,  pathology,  ultrasonography
Kidney Failure, Chronic / epidemiology,  metabolism*
Leptin / blood
Male
Middle Aged
Myocardium / pathology
Neuropeptide Y / blood*
Norepinephrine / blood
Risk Factors
Ventricular Dysfunction, Left / epidemiology,  metabolism*,  pathology,  ultrasonography
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Leptin; 0/Neuropeptide Y; 51-41-2/Norepinephrine
Comments/Corrections
Comment In:
J Hypertens. 2003 Jul;21(7):1263-4   [PMID:  12817170 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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