| Neuropeptide Y and its receptors as potential therapeutic drug targets. | |
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MedLine Citation:
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PMID: 12417094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropeptide Y (NPY) is a 36-amino-acid peptide that exhibits a large number of physiological activities in the central and peripheral nervous systems. NPY mediates its effects through the activation of six G-protein-coupled receptor subtypes named Y(1), Y(2), Y(3), Y(4), Y(5), and y(6). Evidence suggests that NPY is involved in the pathophysiology of several disorders, such as the control of food intake, metabolic disorders, anxiety, seizures, memory, circadian rhythm, drug addiction, pain, cardiovascular diseases, rhinitis, and endothelial cell dysfunctions. The synthesis of agonists and antagonists for these receptors could be useful to treat several of these diseases. |
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Authors:
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Antonio P Silva; Claudia Cavadas; Eric Grouzmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 326 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-05 Completed Date: 2003-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3-25 Citation Subset: IM |
Affiliation:
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Division of Hypertension and Vascular Medicine, Centre Hospitalier Universitaire Vaudois, Av. Pierre Decker, 1011 Lausanne, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Neuropeptide Y / pharmacology*, physiology Receptors, Neuropeptide Y / agonists*, antagonists & inhibitors*, classification, physiology Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/Receptors, Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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