Document Detail

Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.
MedLine Citation:
PMID:  7800854     Owner:  NLM     Status:  MEDLINE    
Neuropeptide Y (NPY) has been established as a potent orexigenic peptide, and recent studies suggest that NPY stimulates cephalic phase secretion as well. However, it is not known whether NPY's effects are pharmacologic or physiologic. In order to determine the physiologic significance of NPY, we examined the effects of two putative NPY receptor antagonists, PYX-1 and PYX-2, on sham feeding and gastric acid secretion in dogs. Our results demonstrate that intracerebroventricular (i.c.v.) injection of PYX-1 and PYX-2 at 1000 pmol/kg doses significantly suppresses the gastric acid response to sham feeding in dogs. The volumes sham fed were not significantly altered with i.c.v. administration of the antagonists. Peripheral administration did not affect acid secretion nor sham feeding volumes. Our data suggest that central administration of the novel NPY antagonists, PYX-1 and PYX-2, results in significant suppression of acid secretion in dogs. This supports our hypothesis that NPY functions as a physiologic modulator of cephalic phase acid secretion.
M C Lee; D C Lawson; T N Pappas
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Regulatory peptides     Volume:  52     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-20     Completed Date:  1995-01-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-34     Citation Subset:  IM    
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Eating / drug effects*
Gastric Acid / secretion*
Neuropeptide Y / analogs & derivatives*,  pharmacology,  physiology*
Peptide Fragments / pharmacology*
Receptors, Neuropeptide Y / antagonists & inhibitors*
Grant Support
1-R29-DK40790-01/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Neuropeptide Y; 0/Peptide Fragments; 0/Receptors, Neuropeptide Y; 140842-17-7/PYX 1; 146999-93-1/PYX 2

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