| Neuropeptide Y: behavioral effects in the golden hamster. | |
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MedLine Citation:
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PMID: 3247255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropeptide Y (NPY) is found abundantly in nervous tissues of vertebrate species including the golden hamster. Centrally-administered NPY has been reported to elicit ingestive behaviors in the rat, squirrel, pig, mouse, and chick. To assess NPY's behavioral effects in a New World rodent that does not increase food intake after deprivation, NPY was injected intracerebroventricularly (10.0-0.04 micrograms/5 microliter) in home-caged golden hamsters with ad lib access to food, water and 5% w/v ethanol solution. Food and fluid intakes, and behavior displays were monitored after NPY injection. NPY promptly increased short-term food intake and observed feeding behaviors at 10.0, 3.3, 1.1, and 0.37 micrograms NPY, but there was no effect on 24 hr food intake. Water and ethanol intakes were increased only at 10.0 and 0.37 micrograms NPY, respectively. Resting behaviors decreased at NPY doses that increased feeding, but there were no consistent effects of NPY on any other category of behavior. Results demonstrate that NPY potently stimulates short-term food intake and decreases resting behavior in the golden hamster. The lack of compensatory food intake in deprived hamsters cannot be explained as an insensitivity to the putative orexigenic function of endogenous neuropeptide Y. |
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Authors:
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P J Kulkosky; G W Glazner; H D Moore; C A Low; S C Woods |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Peptides Volume: 9 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1988 Nov-Dec |
Date Detail:
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Created Date: 1989-06-20 Completed Date: 1989-06-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1389-93 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Southern Colorado, Pueblo 81001. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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drug effects Animals Behavior, Animal / drug effects* Cricetinae Drinking Behavior / drug effects Feeding Behavior / drug effects Female Grooming / drug effects Mesocricetus Motor Activity / drug effects Neuropeptide Y / pharmacology* Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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RR-08197/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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