Document Detail

Neuropeptide Y administered into cerebral ventricles stimulates sucrose ingestion in the near-term ovine fetus.
MedLine Citation:
PMID:  14586332     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In adults, nutrient intake is controlled by opposing actions of appetite stimulants (eg, neuropeptide Y [NPY]) and suppressors (eg, leptin). Because NPY may exert a preferential role in mediating adult carbohydrate intake, we sought to determine the effect of central NPY on near-term fetal carbohydrate ingestion. STUDY DESIGN: Five pregnant ewes and fetuses were prepared with fetal vascular, sublingual, and intracerebroventricular catheters, electrocorticogram, and esophageal electromyogram electrodes and studied at 131+/-2 days' gestation. After a 2-hour baseline period, 10% sucrose was infused sublingually for the duration of the study. At 4 hours' time, NPY was injected into the fetal cerebral ventricles and fetal swallowing monitored for an additional 6 hours. RESULTS: During the basal period, mean (+/-SEM) swallowing averaged 0.8+/-0.1 swallows per minute. Fetal swallowing increased significantly in response to sublingual sucrose (1.3+/-0.1 swallows/min, P=.001), and further significantly increased at 4 to 6 hours after NPY injection into the cerebral ventricles (1.8+/-0.3, P=.001). CONCLUSION: These results indicate central NPY stimulation of fetal ingestion beyond that resulting from sublingual 10% sucrose. The in utero development of NPY-induced ingestive behavior may be in preparation for high neonatal caloric intake.
Mostafa A El-Haddad; Yaser Ismail; Catalina Guerra; Linda Day; Michael G Ross
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  189     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-30     Completed Date:  2003-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  949-52     Citation Subset:  AIM; IM    
Perinatal Research Laboratories, Harbor/UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA.
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MeSH Terms
Cerebral Ventricles / drug effects*
Fetus / physiology*
Injections, Intraventricular
Neuropeptide Y / administration & dosage*
Sheep, Domestic
Stimulation, Chemical
Grant Support
K08 010187-01-00//PHS HHS; R01 DK43311/DK/NIDDK NIH HHS; R03 HD39671-01/HD/NICHD NIH HHS
Reg. No./Substance:
0/Neuropeptide Y; 57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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