Document Detail

Neuropeptide Y (NPY) reduces field stimulation-evoked release of noradrenaline and enhances force of contraction in the rat portal vein.
MedLine Citation:
PMID:  3838576     Owner:  NLM     Status:  MEDLINE    
The effect of neuropeptide Y (NPY) on fractional tritium-noradrenaline (3H-NA) release and contractile activity was studied in the isolated portal vein of SHR and WKY rats. NPY (5 X 10(-7) M) enhanced the force of the spontaneous contractile activity by about 40%. The fractional 3H-release elicited by transmural nerve stimulation (TNS), which mainly reflects 3H-NA, was reduced by about 40% after preincubation with 5 X 10(-7) M NPY in portal veins from both SHR and WKY rats. The inhibitory effect of NPY on TNS-evoked 3H-release was more slowly reversed by washout than the facilitatory action on spontaneous contractile force. The contractile response to field stimulation was not reduced by NPY, but rather tended to be increased. It is concluded that NPY exerts a dual action in the SHR and WKY portal vein, thus enhancing the smooth muscle contractions and inhibiting sympathetic neurotransmission. The inhibitory effect of NPY on TNS-evoked NA efflux, which is present in both SHR and WKY rats, is most likely due to a presynaptic site of action.
C Dahlöf; P Dahlöf; K Tatemoto; J M Lundberg
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  328     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-05-15     Completed Date:  1985-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  327-30     Citation Subset:  IM    
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MeSH Terms
Electric Stimulation
Muscle Contraction / drug effects*
Muscle, Smooth, Vascular / drug effects*
Nerve Tissue Proteins / pharmacology*
Neuropeptide Y
Norepinephrine / secretion*
Portal Vein / drug effects
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Neuropeptide Y; 51-41-2/Norepinephrine

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