Document Detail


Neuropeptide Y (NPY) Y2 receptor-selective agonist inhibits food intake and promotes fat metabolism in mice: combined anorectic effects of Y2 and Y4 receptor-selective agonists.
MedLine Citation:
PMID:  17204349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral administration of the endogenous Y(2) and Y(4) receptor selective agonists, PYY(3-36) and PP, have been shown to inhibit food intake and body weight gain in rodents, and to reduce appetite and caloric intake in humans. We have previously developed a long-acting, potent and highly selective Y(2) receptor selective agonist, N-alpha-Ac-[Nle(24,28), Trp(30), Nva(31), Psi(35-36)]PYY(22-36)-NH(2) (BT-48). BT-48 (ip) dose-dependently inhibited ad lib food intake and also decreased the respiratory quotient in mice during both the light and dark periods. The latter observation is indicative of enhanced fat metabolism. Moreover, BT-48 also inhibited food intake in fasted mice. Combined ip administration of BT-48 (50nmol/mouse) with a highly potent and selective Y(4) anorectic peptide, BVD-74D (50nmol/mouse), resulted in a powerful and long lasting inhibitory effect on food intake. As expected, this inhibitory effect on food intake was nearly double that exhibited by either peptide (50nmol/mouse) alone. In summary, BT-48, unlike PYY(3-36), exhibits little or no affinity to other "Y" receptors, and may therefore have a better clinical potential than PYY(3-36) for control of food intake. Moreover, it appears that treatment with a combination of Y(2) and Y(4) receptor selective agonists may constitute a more powerful approach to control food intake than treatment with either of these agonists alone.
Authors:
Ambikaipakan Balasubramaniam; Rashika Joshi; Chunhua Su; Lou Ann Friend; J Howard James
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Publication Detail:
Type:  Journal Article     Date:  2007-01-03
Journal Detail:
Title:  Peptides     Volume:  28     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-40     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA. ambi.bala@uc.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Animals
Appetite Depressants / pharmacology*
Feeding Behavior / drug effects*
Male
Mice
Receptors, Neuropeptide Y / agonists*
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y2 receptor; 0/neuropeptide Y4 receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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