| Neuropeptide Y Leu7Pro Polymorphism Associated With the Metabolic Syndrome and Its Features in Patients With Coronary Artery Disease. | |
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MedLine Citation:
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PMID: 22308535 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The metabolic syndrome (MetS) is characterized by constellation of clinical and biochemical features that increase the risk of cardiovascular disease. Neuropeptide Y (NPY) is a neurotransmitter and enhances the development of obesity and other aspects of MetS. We determined the association between NPY Leu7Pro polymorphism and features of MetS in Iranian patients with coronary artery disease (CAD). A total of 550 patients with CAD including individuals with (n = 184) and without MetS (n = 366) were genotyped by polymerase chain reaction-restriction fragment length polymorphism. A significantly higher frequency of the Leu7Pro polymorphism was found in patients with MetS compared with the non-MetS patients (P = .001). Furthermore, there was a significant difference in Pro7 frequency between diabetics versus nondiabetics (P = .005), dyslipidemic versus nondyslipidemic (P = .04), and obese versus nonobese (P = .001) in this population. Leu7Pro polymorphism is associated with the MetS in patients with CAD. |
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Authors:
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Ali Masoudi Kazemabad; Khadijeh Jamialahmadi; Mohsen Moohebati; Majid Mojarrad; Raheleh Dehghan Manshadi; Saeed Akhlaghi; Gordon A Ferns; Majid Ghayour-Mobarhan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-3 |
Journal Detail:
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Title: Angiology Volume: - ISSN: 1940-1574 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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