Document Detail


Neuropeptide receptors in intestinal disease: physiology and therapeutic potential.
MedLine Citation:
PMID:  20030609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The autonomous nervous system of the gut is increasingly recognized as an important regulatory factor in intestinal permeability and immune cell activation. Neuropeptides released by neurons -or inflammatory cells- have emerged as neuro-immune modulators that can relay, for instance, stress-induced neuronal activity to immune processes. Such peptides can participate in processes reducing inflammatory responses, or augment resolution of inflammation. Neuropeptides and hormones such as vasoactive intestinal peptide, urocortin, ghrelin, and cortistatin have been shown to modulate the disease activity in a variety of experimental models of inflammatory and autoimmune disease via modulation of immune or neuronal cell activity. We review here the potential of neuropeptide receptor activation to modulate inflammatory diseases of the intestine. We will highlight the role of neuropeptides in gastrointestinal (GI) physiology and immune regulation, and we will speculate on the therapeutic potential of peptides that bind G protein coupled receptors (GPCRs) in the management of inflammation in the GI tract.
Authors:
Susanne A Snoek; Keren S Borensztajn; Ren? M van den Wijngaard; Wouter J de Jonge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  16     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1091-105     Citation Subset:  IM    
Affiliation:
Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Meibergdreef 9, 1105 AZ Amsterdam.
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System / physiology
Gastroenteritis / drug therapy*,  metabolism
Gastrointestinal Tract / drug effects,  innervation,  physiology*
Humans
Immune System / physiology
Models, Biological
Neuropeptides / pharmacology,  therapeutic use*
Receptors, Neuropeptide / drug effects*,  physiology*
Chemical
Reg. No./Substance:
0/Neuropeptides; 0/Receptors, Neuropeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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