| Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation by the cAMP-PKA pathway. | |
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MedLine Citation:
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PMID: 22532103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Our novel findings document the importance of PACAP-mediated cAMP-PKA signaling in hepatic homeostasis and cytoprotection in vivo. Because the enhancement of neural modulation differentially regulates local inflammation and prevents hepatocyte death, these results provide the rationale for novel approaches to manage liver inflammation and IRI in transplant patients. |
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Authors:
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Haofeng Ji; Yu Zhang; Xiu-da Shen; Feng Gao; Cynthia Y Huang; Catalina Abad; Ronald W Busuttil; James A Waschek; Jerzy W Kupiec-Weglinski |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2013-01-18 |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 57 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-03-04 Completed Date: 2013-04-23 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 1225-37 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Association for the Study of Liver Diseases. |
Affiliation:
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Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / immunology Cells, Cultured Cyclic AMP / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Hepatocytes / immunology, metabolism, pathology Homeostasis / immunology Immunologic Factors / immunology, metabolism* Liver Diseases / immunology, metabolism*, pathology Macrophages / cytology, drug effects, immunology Male Mice Mice, Inbred C57BL Mice, Knockout Necrosis / immunology Pituitary Adenylate Cyclase-Activating Polypeptide / genetics, metabolism*, pharmacology Reperfusion Injury / immunology, metabolism*, pathology Signal Transduction / immunology* Toll-Like Receptor 4 / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK062357-06S1/DK/NIDDK NIH HHS; R01 DK062357/DK/NIDDK NIH HHS; R01 DK062357/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adcyap1 protein, mouse; 0/Immunologic Factors; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 0/Tlr4 protein, mouse; 0/Toll-Like Receptor 4; 60-92-4/Cyclic AMP; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases |
| Comments/Corrections | |
Comment In:
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Hepatology. 2013 Mar;57(3):878-80
[PMID:
22729815
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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