| Neuropathology of spongiform encephalopathies in humans. | |
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MedLine Citation:
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PMID: 8137127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The historical aspects and classification of human spongiform encephalopathies are reviewed and the newer concept of 'prion dementias' is explored. Guidelines for safe laboratory and autopsy handling of spongiform encephalopathy tissues are outlined: this includes an update on strategies which are currently thought to be effective in decontamination. A wide ranging review of the pathology of the various human spongiform encephalopathies includes newly emerging data on microglia, and cell-specific and neurodegenerative proteins. A large section of this chapter is devoted to the methodology of immunocytochemical demonstration of PrP in tissue sections, and the dilemmas inherent in interpretation. Clinicopathological correlations are provided for classical cases of spongiform encephalopathy, together with the newly recognised atypical dementias associated with PrP gene mutations. The pathology of iatrogenic cases of CJD is described. The chapter concludes with problems in differential diagnosis, and discussion of the histopathological features which help to resolve diagnostic dilemmas. |
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Authors:
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J E Bell; J W Ironside |
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Publication Detail:
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Type: Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: British medical bulletin Volume: 49 ISSN: 0007-1420 ISO Abbreviation: Br. Med. Bull. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-04-25 Completed Date: 1994-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376542 Medline TA: Br Med Bull Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 738-77 Citation Subset: IM; Q |
Affiliation:
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Department of Pathology (Neuropathology), University of Edinburgh, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebellum
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pathology Creutzfeldt-Jakob Syndrome / pathology Diagnosis, Differential History, 20th Century Humans Mutation Prion Diseases* / classification, history, pathology Prions / immunology |
| Chemical | |
Reg. No./Substance:
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0/Prions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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