Document Detail

Neuropathology of spongiform encephalopathies in humans.
MedLine Citation:
PMID:  8137127     Owner:  NLM     Status:  MEDLINE    
The historical aspects and classification of human spongiform encephalopathies are reviewed and the newer concept of 'prion dementias' is explored. Guidelines for safe laboratory and autopsy handling of spongiform encephalopathy tissues are outlined: this includes an update on strategies which are currently thought to be effective in decontamination. A wide ranging review of the pathology of the various human spongiform encephalopathies includes newly emerging data on microglia, and cell-specific and neurodegenerative proteins. A large section of this chapter is devoted to the methodology of immunocytochemical demonstration of PrP in tissue sections, and the dilemmas inherent in interpretation. Clinicopathological correlations are provided for classical cases of spongiform encephalopathy, together with the newly recognised atypical dementias associated with PrP gene mutations. The pathology of iatrogenic cases of CJD is described. The chapter concludes with problems in differential diagnosis, and discussion of the histopathological features which help to resolve diagnostic dilemmas.
J E Bell; J W Ironside
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  British medical bulletin     Volume:  49     ISSN:  0007-1420     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-04-25     Completed Date:  1994-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  738-77     Citation Subset:  IM; Q    
Department of Pathology (Neuropathology), University of Edinburgh, UK.
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MeSH Terms
Cerebellum / pathology
Creutzfeldt-Jakob Syndrome / pathology
Diagnosis, Differential
History, 20th Century
Prion Diseases* / classification,  history,  pathology
Prions / immunology
Reg. No./Substance:

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