Document Detail


Neuropathology of progressive cognitive decline in chronically hypertensive rhesus monkeys.
MedLine Citation:
PMID:  11271369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is an identified major risk factor for cerebrovascular disease, which is second only to Alzheimer's disease as a cause of dementia in the elderly. In addition, hypertension has been associated with a more subtle, progressive decline in cognitive function for which the neuropathology is not well understood. The present study was undertaken to explore this relationship in an experimental, nonhuman primate model, with hypertension produced by a coarctation of the thoracic aorta. Since prior studies with this model have shown a progressive decline in memory function, similar to that seen in human hypertension, as well as scattered microinfarcts in the cerebral white and gray matter, this study was designed to explore the relationship between these two. In addition to microinfarcts, the hypertensive monkeys with the highest arterial blood pressure also showed minute areas of focal gliosis without infarction. The number of these focal lesions showed a significant correlation with the severity of the hypertension, but not with the behavioral deficit. For four of these hypertensive monkeys, immunostaining demonstrated a pervasive, widespread activation of microglial cells and astroglial cells in the white matter as well as evidence of leaks in the blood-brain barrier, providing a more logical substrate for the cognitive decline.
Authors:
T L Kemper; G J Blatt; R J Killiany; M B Moss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta neuropathologica     Volume:  101     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  145-53     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA. tkemper@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / pathology
Cerebral Cortex / pathology*,  physiopathology
Cerebrovascular Disorders / etiology*,  pathology*,  physiopathology
Cognition Disorders / etiology*,  pathology*,  physiopathology
Disease Models, Animal
Glial Fibrillary Acidic Protein / analysis
Gliosis / etiology,  pathology,  physiopathology
Hypertension / complications*
Immunohistochemistry
Macaca mulatta
Memory Disorders / etiology,  pathology,  physiopathology
Microglia / pathology
Nerve Degeneration / etiology,  pathology,  physiopathology
Neuropsychological Tests
Grant Support
ID/Acronym/Agency:
NS31649/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein

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