Document Detail

Neuropathology of late cortical cerebellar atrophy in Japan: distribution of cerebellar change on an autopsy case and review of Japanese cases.
MedLine Citation:
PMID:  7995299     Owner:  NLM     Status:  MEDLINE    
We report a Japanese autopsy case of late cortical cerebellar atrophy. The patient had showed clinically transient remission during thyrotropin-releasing hormone therapy. Our case suggests that thyrotropin-releasing hormone therapy is worth trying as a treatment of late cortical cerebellar atrophy. Neuropathological examination showed diffuse cerebellar cortical lesions and absence of neuronal loss in the dorsomedial part of the inferior olives. We studied qualitatively the detailed distribution of the cerebellar cortical lesions in 6 sections of the right cerebellum. The cerebellar lesions were more conspicuous in the most lateral hemisphere than in the vermis. We also reviewed 7 Japanese autopsy cases of late cortical cerebellar atrophy.
K Tsuchiya; E Ozawa; F Saito; H Irie; T Mizutani
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European neurology     Volume:  34     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1994  
Date Detail:
Created Date:  1995-01-19     Completed Date:  1995-01-19     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  253-62     Citation Subset:  IM    
Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Cerebellar Cortex / drug effects,  pathology*
Cerebellar Diseases / drug therapy,  pathology*
Cerebral Cortex / drug effects,  physiology
Diagnosis, Differential
Intracranial Arteriosclerosis / drug therapy,  pathology
Purkinje Cells / drug effects,  pathology
Spinocerebellar Degenerations / drug therapy,  pathology
Thyrotropin-Releasing Hormone / therapeutic use
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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