Document Detail

Neuropathology of the dentate nucleus in developmental disorders.
MedLine Citation:
PMID:  9224528     Owner:  NLM     Status:  MEDLINE    
The dentate nucleus was examined histologically and immunohistochemically in 47 cases of nonprogressive developmental disorders. Neuronal loss and/or atrophy was observed in 13 cases, while mild neuronal lesions, characterized by dendritic swelling and/or the appearance of eosinophilic materials around the neurons, were exhibited in 20 cases. The former change was accompanied by diffuse central nervous system involvement, and the etiology was perinatal hypoxic ischemic encephalopathy, acute encephalopathy, and meningoencephalitis in most cases. On the other hand, most of the patients with kernicterus showed the latter change. Immunohistochemically, the mild neuronal lesions mimicking grumose, degeneration, described in some neurodegenerative diseases, seemed to reflect the changes of Purkinje cell terminals. It is suggested that secondary structural alteration of the dentate neurons in the absence of severe atrophy can occur in nonprogressive developmental disorders.
S Kumada; M Hayashi; R Umitsu; N Arai; J Nagata; K Kurata; Y Morimatsu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  94     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-19     Completed Date:  1997-08-19     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  36-41     Citation Subset:  IM    
Department of Pediatrics, Musashino Red Cross Hospital, Tokyo, Japan.
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MeSH Terms
Brain Diseases / etiology,  metabolism,  pathology*
Cerebellar Nuclei / chemistry,  pathology*
Child, Preschool
Developmental Disabilities / etiology,  metabolism,  pathology*
Machado-Joseph Disease / metabolism,  pathology
Middle Aged
Nerve Tissue Proteins / analysis
Neurons / chemistry,  pathology
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/atrophin-1

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