| Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia. | |
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MedLine Citation:
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PMID: 16580728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A wide range of neuropathological abnormalities have been detected in schizophrenia sufferers, and emerging evidence points to neural substrates of connectivity as having a key role in the development of disease. This article reviews the available evidence for white matter pathology in schizophrenia, and examines its possible role as a substrate of impaired connectivity. Neuropathological data is suggestive of abnormalities in glial structure and function, and myelinated structures have also been implicated. A number of studies, particularly using gene array technology, are pointing towards significant disruption in expression of myelination genes. Magnetic resonance imaging has tended to focus on, and detect, more grey than white matter abnormalities, although non-volumetric techniques are suggestive of changes in the microstructure of white matter in schizophrenia. Myelinated structures are an attractive candidate for an anatomical substrate for disconnectivity, and may act synergistically with synaptic changes to result in functional disconnectivity although the relationship between white and grey matter changes in the illness remains unclear. |
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Authors:
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Mark Walterfang; Stephen J Wood; Dennis Velakoulis; Christos Pantelis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-03-31 |
Journal Detail:
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Title: Neuroscience and biobehavioral reviews Volume: 30 ISSN: 0149-7634 ISO Abbreviation: Neurosci Biobehav Rev Publication Date: 2006 |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2006-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: United States |
Other Details:
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Languages: eng Pagination: 918-48 Citation Subset: IM |
Affiliation:
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Melbourne Neuropsychiatry Centre, University of Melbourne, Victoria, Australia. mark.walterfang@mh.org.au <mark.walterfang@mh.org.au> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / pathology* Brain Mapping* Humans Magnetic Resonance Imaging* Schizophrenia* / genetics, pathology, physiopathology |
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