Document Detail

Neuropathological features of Alzheimer's disease in non-demented parkinsonian patients.
MedLine Citation:
PMID:  1800669     Owner:  NLM     Status:  MEDLINE    
Two patients with levodopa-responsive Parkinson's syndrome had numerous cortical and striatal senile plaques and some neurofibrillary tangles at necropsy. In addition neurons in the pars compacta of the substantia nigra were severely depleted but there were no Lewy bodies or other neuropathological changes to account for parkinsonism. Neither patient was demented. These pathological findings have not previously been described as a cause of Parkinson's syndrome without associated dementia of Alzheimer's disease type.
S E Daniel; A J Lees
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  54     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  972-5     Citation Subset:  IM    
Society Brain Bank, Institute of Neurology, London, UK.
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MeSH Terms
Alzheimer Disease / pathology*
Brain / pathology*
Corpus Striatum / pathology
Neurofibrillary Tangles / pathology
Parkinson Disease / pathology*
Substantia Nigra / pathology

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