Document Detail

Neuropathological correlates of reversible posterior leukoencephalopathy.
MedLine Citation:
PMID:  16159081     Owner:  NLM     Status:  MEDLINE    
The pathogenesis and neuropathology of reversible posterior leukoencephalopathy (RPLE; a clinical and radiographical syndrome linked to malignant hypertension, eclampsia, immunosuppressive drugs, and chemotherapy) remain poorly understood. Autopsies on patients with hypertensive encephalopathy have demonstrated arteriolar fibrinoid necrosis with micro-infarcts and failed to show brain edema; nonetheless, magnetic resonance imagings (MRIs) of patients with RPLE generally show findings most consistent with vasogenic edema. This article reports a patient with RPLE in whom brain biopsy revealed edematous white matter with no evidence of vessel wall damage or infarction. This supports the concept that the imaging changes on MRI represent vasogenic edema and suggests that the changes observed on autopsy in malignant hypertension may be an epiphenomenon.
David Schiff; Maria-Beatriz Lopes
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurocritical care     Volume:  2     ISSN:  1541-6933     ISO Abbreviation:  Neurocrit Care     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-14     Completed Date:  2005-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-5     Citation Subset:  IM    
Division of Neuro-Oncology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.
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MeSH Terms
Brain Edema / pathology*
Dementia, Vascular / pathology*
Hypertensive Encephalopathy / pathology*
Magnetic Resonance Imaging
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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