Document Detail

Neuropathological associates of multiple cognitive functions in two community-based cohorts of older adults.
MedLine Citation:
PMID:  21092373     Owner:  NLM     Status:  MEDLINE    
Studies of neuropathology-cognition associations are not common and have been limited by small sample sizes, long intervals between autopsy and cognitive testing, and lack of breadth of neuropathology and cognition variables. This study examined domain-specific effects of common neuropathologies on cognition using data (N = 652) from two large cohort studies of older adults. We first identified dimensions of a battery of 17 neuropsychological tests, and regional measures of Alzheimer's disease (AD) neuropathology. We then evaluated how cognitive factors were related to dimensions of AD and additional measures of cerebrovascular and Lewy Body disease, and also examined independent effects of brain weight. All cognitive domains had multiple neuropathology determinants that differed by domain. Neocortical neurofibrillary tangles were the strongest predictors of most domains, while medial temporal tangles showed a weaker relationship with episodic memory. Neuritic plaques had relatively strong effects on multiple domains. Lewy bodies and macroscopic infarcts were associated with all domains, while microscopic infarcts had more limited associations. Brain weight was related to all domains independent of specific neuropathologies. Results show that cognition is complexly determined by multiple disease substrates. Neuropathological variables and brain weight contributed approximately a third to half of the explained variance in different cognitive domains.
N Maritza Dowling; Sarah Tomaszewski Farias; Bruce R Reed; Joshua A Sonnen; Milton E Strauss; Julie A Schneider; David A Bennett; Dan Mungas
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  17     ISSN:  1469-7661     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-03-12     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  602-14     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aging / psychology
Alzheimer Disease / psychology
Brain / pathology
Cerebral Infarction / pathology
Cerebrovascular Disorders / psychology
Cognition / physiology*
Cohort Studies
Factor Analysis, Statistical
Lewy Body Disease / psychology
Longitudinal Studies
Memory / physiology
Nervous System Diseases / pathology,  psychology*
Plaque, Amyloid / pathology
Visual Perception / physiology
Grant Support
AG10161/AG/NIA NIH HHS; AG17917/AG/NIA NIH HHS; P30 AG010161/AG/NIA NIH HHS; P30 AG010161-21/AG/NIA NIH HHS; P30AG10161/AG/NIA NIH HHS; R01 AG010220/AG/NIA NIH HHS; R01 AG015819/AG/NIA NIH HHS; R01 AG015819-13/AG/NIA NIH HHS; R01 AG017917/AG/NIA NIH HHS; R01AG15819/AG/NIA NIH HHS; R13 AG030995/AG/NIA NIH HHS; R13 AG030995-04/AG/NIA NIH HHS; R13AG030995/AG/NIA NIH HHS
Comment In:
J Int Neuropsychol Soc. 2011 Jul;17(4):639-42   [PMID:  21554784 ]

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