Document Detail

Neuropathologic findings in idiopathic opsoclonus and myoclonus. Their similarity to those in paraneoplastic cerebellar cortical degeneration.
MedLine Citation:
PMID:  2947929     Owner:  NLM     Status:  MEDLINE    
The neuropathologic findings in an idiopathic case of the opsoclonus/myoclonus syndrome are reported. Although neurologic dysfunction may have been more widespread, structural lesions were limited to the cerebellum and inferior olives. Severe depletion of Purkinje cells with preservation of granular cells was evident throughout the neo- and paleocerebellum; however, groups of Purkinje cells were preserved in the archicerebellum. No abnormalities were evident in the paramedian pontine reticular formation of the caudal pons. Inflammation and evidence of anoxic damage were absent. These changes are very similar to those described in paraneoplastic cerebellar cortical degeneration.
S Hunter; C Kooistra
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuro-ophthalmology     Volume:  6     ISSN:  0272-846X     ISO Abbreviation:  J Clin Neuroophthalmol     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-02-10     Completed Date:  1987-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109051     Medline TA:  J Clin Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  236-41     Citation Subset:  IM    
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MeSH Terms
Cerebellum / pathology*
Eye Movements*
Fever of Unknown Origin / physiopathology
Middle Aged
Myoclonus / pathology*
Olivary Nucleus / pathology
Paraneoplastic Syndromes / pathology
Purkinje Cells / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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