| Neuropathologic features, including pontine schwannosis, in a four-year survivor of probable Reye's syndrome with secondary Möbius syndrome. | |
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MedLine Citation:
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PMID: 6723427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Frequent seizures and loss of motor, language, and intellectual skills necessitated care in an institution for the physically and mentally handicapped for 4 years after diagnosis of presumed Reye's syndrome in a 10-month-old boy. M obius syndrome was diagnosed and bilateral tarsorrhaphy performed for exposure keratitis. Postmortem examination revealed multiple old boundary zone infarcts in the cerebral cortex, small cavitated infarcts in basal ganglia and thalami, diffuse neuronal loss and gliosis, and a focus of old necrosis in the pons; brain stem herniation during the acute phase of Reye's syndrome was responsible for the latter lesion. Irregular congeries of proliferated peripheral nerves, confirmed by ultrastructural study, were ramifying in the gliotic pontine tegmentum. The pathologic substrate for the neurovegetative state in a long-term survivor of probable Reye's syndrome appears to be multifocal cerebral infarction. |
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Authors:
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H J Manz; W Cochran |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Child's brain Volume: 11 ISSN: 0302-2803 ISO Abbreviation: Childs Brain Publication Date: 1984 |
Date Detail:
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Created Date: 1984-07-19 Completed Date: 1984-07-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505428 Medline TA: Childs Brain Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 126-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrophy Axons / ultrastructure Cerebral Cortex / pathology Child, Preschool Facial Paralysis / pathology* Humans Male Microscopy, Electron Nerve Fibers, Myelinated / ultrastructure Nerve Regeneration* Pons / pathology* Reye Syndrome / pathology* Schwann Cells / ultrastructure* |
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