Document Detail

Neuropathologic features of Aleutian disease in farmed mink in Ireland and molecular characterization of Aleutian mink disease virus detected in brain tissues.
MedLine Citation:
PMID:  20093694     Owner:  NLM     Status:  MEDLINE    
A neuropathologic survey was conducted on mink brains from the 5 licensed mink farms in Ireland. The survey was part of a transmissible spongiform encephalopathy surveillance study. Aleutian disease (AD) was present on 4 of the 5 farms (80%). Neuropathologic features of nonsuppurative meningoencephalitis were common in mink from the 4 affected farms but were absent in the mink from the fifth farm, which was free of AD. The meningoencephalitis was characterized by infiltrates of lymphocytes and plasma cells, which were present in meninges, perivascular spaces, and the brain parenchyma. Fibrinoid necrotizing arteritis was seen in 11 mink brains, all of which were obtained from a single farm. Aleutian mink disease virus (AMDV) sequences for the capsid protein VP2 were obtained from brain samples from all affected farms. Although containing previously unreported amino acid residues, similarities with European and North American isolates were observed in the hypervariable regions within VP2, suggesting Irish AMDV is related to those isolates. The predicted amino acid residues, suspected of conferring pathogenicity at certain positions of the VP2 sequence, were present in the viral nucleic acid sequences.
Hanne Jahns; Paul Daly; Maire C McElroy; Donal J Sammin; Hugh F Bassett; John J Callanan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc     Volume:  22     ISSN:  1040-6387     ISO Abbreviation:  J. Vet. Diagn. Invest.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011490     Medline TA:  J Vet Diagn Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
Veterinary Sciences Section, School of Agriculture, Food Science and Veterinary Medicine, Veterinary Sciences Centre, R 010 University College Dublin, Belfield, Dublin 14, Ireland.
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MeSH Terms
Aleutian Mink Disease / epidemiology,  pathology*
Aleutian Mink Disease Virus / genetics*,  isolation & purification
Amino Acid Sequence
Brain / virology*
Capsid Proteins / chemistry,  genetics,  metabolism
Central Nervous System Diseases / pathology,  veterinary,  virology
Gene Expression Regulation, Viral
Ireland / epidemiology
Reg. No./Substance:
0/Capsid Proteins; 0/VP2 protein, Aleutian mink disease virus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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