Document Detail


Neuropathologic examination after 91 ECT treatments in a 92-year-old woman with late-onset depression.
MedLine Citation:
PMID:  17548979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whereas pathological seizure states, such as temporal lobe epilepsy, are commonly associated with cell loss and glial scarring in the hippocampus, seizures induced via electroconvulsive therapy (ECT) have not been associated with histological evidence of neuronal damage. We present a case report including the late-life medical history and postmortem histology of an elderly woman with major depression who received 91 sessions of ECT during the last 22 years of her life. Given the large number of ECT sessions, and her advanced age, this case provides a strong test of whether ECT causes detectable evidence of neuronal damage. We examined the gross morphology of the hippocampus, hippocampal cytoarchitecture, and measures of neuropathology. We found no pathological changes that could be attributed to ECT. Only expected, age-related features were present. Corpora amylacea and rare neurofibrillary tangles were evident, but we failed to detect any obvious evidence of cell loss or gliosis. Cognition in this patient was intact as indicated by a perfect score on a Mini-Mental Status Examination administered 6 days before death at the age of 92. This case adds to the considerable evidence for the safety of ECT.
Authors:
Jason Scalia; Sarah H Lisanby; Andrew J Dwork; James E Johnson; Elisabeth R Bernhardt; Victoria Arango; W Vaughn McCall
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of ECT     Volume:  23     ISSN:  1095-0680     ISO Abbreviation:  J ECT     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-08-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  9808943     Medline TA:  J ECT     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. js2406@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Autopsy
Brain / pathology*
Depression / pathology*,  therapy*
Electroconvulsive Therapy*
Female
Humans
Photomicrography
Grant Support
ID/Acronym/Agency:
T32 MH020004/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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